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Hypertension (High Blood Pressure): Metolazone belongs to a class of medications called thiazide-like diuretics. It works by increasing the excretion of sodium and water by the kidneys, which leads to a decrease in blood volume and subsequently lowers blood pressure. This helps to reduce the risk of complications associated with hypertension, such as stroke, heart attack, and kidney problems.
Edema (Fluid Retention): Metolazone is used to treat edema associated with congestive heart failure, liver cirrhosis, kidney disease, and other conditions. By promoting diuresis (increased urine production), metolazone helps to remove excess fluid from the body, relieving swelling and reducing the workload on the heart.
Congestive Heart Failure: In congestive heart failure, the heart is unable to pump blood effectively, leading to fluid buildup in the lungs and other tissues. Metolazone helps to alleviate symptoms of fluid overload by removing excess fluid from the body and improving cardiac function.
Nephrotic Syndrome: Metolazone may be used in the treatment of nephrotic syndrome, a kidney disorder characterized by proteinuria (excess protein in the urine), edema, hypoalbuminemia (low levels of albumin in the blood), and hyperlipidemia (elevated blood lipid levels). It helps to reduce edema and fluid retention associated with this condition.
Ascites: Metolazone may be prescribed to manage ascites, which is the accumulation of fluid in the abdominal cavity often seen in individuals with liver cirrhosis or certain types of cancer. By increasing urine output, it helps to reduce the volume of fluid in the body and alleviate symptoms.
Hypocalcemia: In some cases, metolazone may be used to treat hypocalcemia (low blood calcium levels) associated with certain medical conditions. It works by increasing renal calcium excretion, which helps to restore normal calcium levels in the blood.
We extend modifiers to include items that changes the parent and child taxa. I.e. for a species, that would be the genus that is belongs to and the strains in the species.
A higher number indicates impact on more bacteria associated with the condition and confidence on the impact.
We have X bacteria high and Y low reported. We find that the modifier reduces some and increases other of these two groups. We just tally: X|reduces + Y|Increase = Positive β X|increases + Y|decrease = Negative.
Benefit Ratio:
Numbers above 0 have increasing positive effect.
Numbers below 0 have increasing negative effect.