🍽️ sildenafil,(prescription)

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  1. Pulmonary Vasodilation: Sildenafil works by relaxing the smooth muscle cells in the walls of the pulmonary arteries, leading to vasodilation (widening of the blood vessels) and reducing the resistance to blood flow in the lungs. This helps lower pulmonary arterial pressure and improve exercise capacity in patients with PAH.

  2. Treatment of PAH: Sildenafil is indicated for the treatment of PAH in adults to improve exercise ability and delay clinical worsening. It is typically taken orally, either as immediate-release tablets or as a suspension, and the dosage may vary depending on individual factors such as weight, severity of PAH, and response to treatment.

  3. Adverse Effects: Common side effects of sildenafil for PAH may include headache, flushing, dyspepsia, nasal congestion, and diarrhea. Serious side effects such as hypotension (low blood pressure), syncope (fainting), and visual disturbances are less common but may occur, especially at higher doses.

  4. Monitoring: Patients taking sildenafil for PAH may require regular monitoring of blood pressure, liver function tests, and exercise capacity to assess treatment response and detect any potential adverse effects. Dose adjustments may be necessary based on individual tolerability and clinical status.

  5. Combination Therapy: In some cases, sildenafil may be used in combination with other medications for PAH, such as prostacyclin analogs or endothelin receptor antagonists, to achieve optimal therapeutic outcomes. Combination therapy should be carefully managed by a healthcare provider familiar with the treatment of PAH.

  6. Long-Term Treatment: Sildenafil is generally well-tolerated for long-term use in patients with PAH, but regular follow-up with a healthcare provider is essential to monitor disease progression, adjust treatment as needed, and address any emerging concerns or complications.

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Impacted of sildenafil,(prescription) On Probiotics

Bacteria Impacted by sildenafil,(prescription)

We extend modifiers to include items that changes the parent and child taxa. I.e. for a species, that would be the genus that is belongs to and the strains in the species.

Impact of sildenafil,(prescription) on Conditions from US National Library of Medicine

A higher number indicates impact on more bacteria associated with the condition and confidence on the impact.

We have X bacteria high and Y low reported. We find that the modifier reduces some and increases other of these two groups. We just tally: X|reduces + Y|Increase = Positive   X|increases + Y|decrease = Negative.

Benefit Ratio:
Numbers above 0 have increasing positive effect.
Numbers below 0 have increasing negative effect.

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