AI Engines For more Details: Perplexity Kagi Labs You
Hypothyroidism: Liothyronine is prescribed to supplement or replace the deficient levels of thyroid hormone in individuals with hypothyroidism. By providing exogenous T3, liothyronine helps restore normal thyroid hormone levels in the body, alleviating symptoms such as fatigue, weight gain, cold intolerance, dry skin, and constipation.
Thyroid Hormone Replacement Therapy: Liothyronine is often used as part of thyroid hormone replacement therapy, either alone or in combination with levothyroxine (T4), another synthetic thyroid hormone. Combination therapy may be prescribed in cases where patients do not respond adequately to levothyroxine alone or have difficulty converting T4 to T3.
Thyroid Cancer: In some cases, liothyronine may be used as part of the management of thyroid cancer, particularly in patients undergoing thyroid hormone suppression therapy after thyroidectomy (surgical removal of the thyroid gland). Thyroid hormone suppression therapy aims to reduce the production of thyroid-stimulating hormone (TSH), which can stimulate the growth of residual thyroid cancer cells.
Diagnostic Testing: Liothyronine may be used in diagnostic testing, such as thyroid function tests, to assess thyroid gland function and diagnose thyroid disorders. It may be administered in conjunction with other thyroid hormones or medications as part of a comprehensive evaluation of thyroid function.
Dosage Adjustment: The dosage of liothyronine is individualized based on factors such as the patient's age, weight, underlying health conditions, and response to treatment. Regular monitoring of thyroid function tests is necessary to ensure that thyroid hormone levels are within the therapeutic range and to adjust the dosage as needed.
Adverse Effects: Common side effects of liothyronine therapy may include palpitations, tachycardia (rapid heart rate), arrhythmias, tremors, nervousness, insomnia, sweating, heat intolerance, and diarrhea. These side effects are usually dose-related and may indicate overtreatment with thyroid hormone.
Cardiovascular Effects: Liothyronine can have significant cardiovascular effects, especially when used in excessive doses. It may exacerbate preexisting cardiovascular conditions such as angina, hypertension, and heart failure. Patients with cardiovascular disease should be monitored closely during liothyronine therapy.
Pregnancy and Lactation: Liothyronine therapy may need to be adjusted during pregnancy and lactation to maintain adequate thyroid hormone levels for maternal and fetal health. Pregnant women with hypothyroidism require careful monitoring and adjustment of thyroid hormone replacement to prevent complications such as miscarriage, preterm birth, and developmental abnormalities in the baby.
| Rank | Probiotic | Impact |
|---|---|---|
| genus | Bifidobacterium | Reduces |
| species | Akkermansia muciniphila | Reduces |
| species | Bifidobacterium adolescentis | Reduces |
| species | Bifidobacterium longum | Reduces |
| species | Lacticaseibacillus paracasei | Reduces |
| subspecies | Bifidobacterium longum subsp. infantis | Reduces |
| subspecies | Bifidobacterium longum subsp. longum | Reduces |
We extend modifiers to include items that changes the parent and child taxa. I.e. for a species, that would be the genus that is belongs to and the strains in the species.
A higher number indicates impact on more bacteria associated with the condition and confidence on the impact.
We have X bacteria high and Y low reported. We find that the modifier reduces some and increases other of these two groups. We just tally: X|reduces + Y|Increase = Positive X|increases + Y|decrease = Negative.
Benefit Ratio:
Numbers above 0 have increasing positive effect.
Numbers below 0 have increasing negative effect.
| Condition | Positive Impact | Negative Impact | Benefit Ratio Impact |
|---|---|---|---|
| Abdominal Aortic Aneurysm | 0.2 | 0.2 | |
| Acne | 0.6 | 0.3 | 1 |
| ADHD | 3.7 | 0.6 | 5.17 |
| Age-Related Macular Degeneration and Glaucoma | 1.1 | 0.4 | 1.75 |
| Allergic Rhinitis (Hay Fever) | 2.1 | 1.7 | 0.24 |
| Allergies | 3.4 | 2.1 | 0.62 |
| Allergy to milk products | 1.4 | 1 | 0.4 |
| Alopecia (Hair Loss) | 0.9 | 0.9 | |
| Alzheimer's disease | 3.2 | 5.5 | -0.72 |
| Amyotrophic lateral sclerosis (ALS) Motor Neuron | 2.1 | 0.4 | 4.25 |
| Ankylosing spondylitis | 2.3 | 1.2 | 0.92 |
| Anorexia Nervosa | 1.5 | 2.5 | -0.67 |
| Antiphospholipid syndrome (APS) | 0.9 | 0.9 | |
| Asthma | 4 | 2.1 | 0.9 |
| Atherosclerosis | 1.5 | 1.6 | -0.07 |
| Atrial fibrillation | 3.3 | 1.7 | 0.94 |
| Autism | 5.2 | 6.3 | -0.21 |
| Autoimmune Disease | 0.6 | 1 | -0.67 |
| Barrett esophagus cancer | 0.6 | 0.3 | 1 |
| benign prostatic hyperplasia | 0.3 | -0.3 | |
| Biofilm | 1.1 | 1.1 | |
| Bipolar Disorder | 1.2 | 1.4 | -0.17 |
| Brain Trauma | 0.9 | 1.4 | -0.56 |
| Breast Cancer | 0 | 0 | |
| Cancer (General) | 0.9 | 1.5 | -0.67 |
| Carcinoma | 3.1 | 2.5 | 0.24 |
| Celiac Disease | 1.7 | 3 | -0.76 |
| Cerebral Palsy | 1.4 | 1.1 | 0.27 |
| Chronic Fatigue Syndrome | 2.3 | 3.8 | -0.65 |
| Chronic Kidney Disease | 2.9 | 2.1 | 0.38 |
| Chronic Lyme | 0.6 | 0.8 | -0.33 |
| Chronic Obstructive Pulmonary Disease (COPD) | 2.1 | 2 | 0.05 |
| Chronic Urticaria (Hives) | 0.8 | 0.1 | 7 |
| Coagulation / Micro clot triggering bacteria | 0.7 | 1.1 | -0.57 |
| Cognitive Function | 3 | 1.6 | 0.88 |
| Colorectal Cancer | 5.1 | 1.9 | 1.68 |
| Constipation | 0.9 | 0.5 | 0.8 |
| Coronary artery disease | 1.2 | 2.4 | -1 |
| COVID-19 | 5 | 7.6 | -0.52 |
| Crohn's Disease | 4.5 | 5.2 | -0.16 |
| Cushing's Syndrome (hypercortisolism) | 0.3 | -0.3 | |
| cystic fibrosis | 1.4 | -1.4 | |
| deep vein thrombosis | 1.2 | 1.4 | -0.17 |
| Denture Wearers Oral Shifts | 1.3 | 1.3 | |
| Depression | 6.8 | 8.1 | -0.19 |
| Dermatomyositis | 0.3 | 0.3 | 0 |
| Eczema | 1.1 | 1.5 | -0.36 |
| Endometriosis | 2.2 | 2 | 0.1 |
| Eosinophilic Esophagitis | 0.3 | 0.6 | -1 |
| Epilepsy | 1.5 | 1.1 | 0.36 |
| erectile dysfunction | 1.5 | 0.3 | 4 |
| Fibromyalgia | 2.7 | 1 | 1.7 |
| Functional constipation / chronic idiopathic constipation | 3.5 | 2.7 | 0.3 |
| gallstone disease (gsd) | 1.8 | 1.2 | 0.5 |
| Gastroesophageal reflux disease (Gerd) including Barrett's esophagus | 0.6 | 0.6 | 0 |
| Generalized anxiety disorder | 1.2 | 2.2 | -0.83 |
| giant cell arteritis | 0.2 | -0.2 | |
| Glioblastoma | 0.3 | -0.3 | |
| Gout | 1.5 | 0.8 | 0.88 |
| Graves' disease | 1.9 | 3.2 | -0.68 |
| Gulf War Syndrome | 0.8 | 0.5 | 0.6 |
| Halitosis | 1.2 | 0.3 | 3 |
| Hashimoto's thyroiditis | 2.6 | 0.9 | 1.89 |
| Heart Failure | 3.1 | 1.8 | 0.72 |
| hemorrhagic stroke | 1.3 | 1.3 | |
| Hidradenitis Suppurativa | 1.2 | 0.3 | 3 |
| High Histamine/low DAO | 0.8 | 0.6 | 0.33 |
| hypercholesterolemia (High Cholesterol) | 0.5 | 0.1 | 4 |
| hyperglycemia | 1.6 | 1.1 | 0.45 |
| Hyperlipidemia (High Blood Fats) | 0.6 | 0.3 | 1 |
| hypersomnia | 0.3 | -0.3 | |
| hypertension (High Blood Pressure | 2.9 | 4.2 | -0.45 |
| Hypothyroidism | 0 | 0.6 | 0 |
| Hypoxia | 1.8 | 0.3 | 5 |
| IgA nephropathy (IgAN) | 1.6 | 2.7 | -0.69 |
| Inflammatory Bowel Disease | 5.1 | 6.1 | -0.2 |
| Insomnia | 2.2 | 2.4 | -0.09 |
| Intelligence | 0.8 | 0.8 | |
| Intracranial aneurysms | 1.3 | 0.9 | 0.44 |
| Irritable Bowel Syndrome | 4.5 | 3.7 | 0.22 |
| ischemic stroke | 2.2 | 1.1 | 1 |
| Liver Cirrhosis | 6 | 4 | 0.5 |
| Long COVID | 4.6 | 6.1 | -0.33 |
| Low bone mineral density | 1.1 | -1.1 | |
| Lung Cancer | 0.4 | 0.9 | -1.25 |
| Mast Cell Issues / mastitis | 0.3 | 0.9 | -2 |
| ME/CFS with IBS | 0.6 | 0.9 | -0.5 |
| ME/CFS without IBS | 0.5 | 1.3 | -1.6 |
| membranous nephropathy | 0.3 | 0.3 | |
| Menopause | 1 | 0.6 | 0.67 |
| Metabolic Syndrome | 5 | 5.7 | -0.14 |
| Mood Disorders | 6.8 | 5.8 | 0.17 |
| multiple chemical sensitivity [MCS] | 1 | 1 | |
| Multiple Sclerosis | 4.2 | 4.1 | 0.02 |
| Multiple system atrophy (MSA) | 1.2 | 0.6 | 1 |
| myasthenia gravis | 0.3 | 0.7 | -1.33 |
| neuropathic pain | 2.9 | -2.9 | |
| Neuropathy (all types) | 0.3 | 1.9 | -5.33 |
| neuropsychiatric disorders (PANDAS, PANS) | 0.6 | 0.6 | |
| Nonalcoholic Fatty Liver Disease (nafld) Nonalcoholic | 4.1 | 3.6 | 0.14 |
| NonCeliac Gluten Sensitivity | 0.9 | 0.6 | 0.5 |
| Obesity | 7.5 | 6.6 | 0.14 |
| obsessive-compulsive disorder | 2.3 | 2.4 | -0.04 |
| Osteoarthritis | 1.5 | 1.2 | 0.25 |
| Osteoporosis | 1.6 | 1.2 | 0.33 |
| pancreatic cancer | 0.6 | 0.3 | 1 |
| Parkinson's Disease | 5.2 | 5.9 | -0.13 |
| Polycystic ovary syndrome | 3 | 2.3 | 0.3 |
| Postural orthostatic tachycardia syndrome | 0.2 | 0.6 | -2 |
| Premenstrual dysphoric disorder | 0.6 | 0.4 | 0.5 |
| primary biliary cholangitis | 1.2 | 1.1 | 0.09 |
| Primary sclerosing cholangitis | 2.8 | 1.2 | 1.33 |
| Psoriasis | 2.1 | 2.3 | -0.1 |
| rheumatoid arthritis (RA),Spondyloarthritis (SpA) | 4.7 | 4 | 0.18 |
| Rosacea | 0.6 | 1 | -0.67 |
| Schizophrenia | 4.7 | 3 | 0.57 |
| scoliosis | 0.3 | 0.9 | -2 |
| Sjögren syndrome | 1.8 | 2.2 | -0.22 |
| Sleep Apnea | 2 | 1.4 | 0.43 |
| Slow gastric motility / Gastroparesis | 0.9 | 0.3 | 2 |
| Small Intestinal Bacterial Overgrowth (SIBO) | 1.6 | 0.3 | 4.33 |
| Stress / posttraumatic stress disorder | 2.7 | 2.2 | 0.23 |
| Systemic Lupus Erythematosus | 2.4 | 1.9 | 0.26 |
| Tic Disorder | 0.9 | 1.2 | -0.33 |
| Tourette syndrome | 0.9 | 0.3 | 2 |
| Type 1 Diabetes | 1.8 | 3.1 | -0.72 |
| Type 2 Diabetes | 5.3 | 5.3 | 0 |
| Ulcerative colitis | 3.4 | 4.2 | -0.24 |
| Unhealthy Ageing | 2.8 | 2.5 | 0.12 |
| Vitiligo | 1.9 | 1.1 | 0.73 |
