Plasmodium falciparum RO-33 Details: NCBI 5834, gram-negative or unknown [strain]
Severe Malaria: Plasmodium falciparum infection can lead to severe and potentially life-threatening malaria. Symptoms include high fever, chills, sweating, headache, nausea, vomiting, muscle pain, and weakness.
Cerebral Malaria: In severe cases, Plasmodium falciparum can lead to cerebral malaria, a serious complication characterized by altered consciousness, seizures, coma, and neurological deficits. It is associated with a high mortality rate, especially in children.
Anemia: Plasmodium falciparum infection can cause hemolysis (destruction of red blood cells), leading to anemia. Severe anemia can result in fatigue, weakness, shortness of breath, and other complications.
Organ Dysfunction: Severe malaria can lead to dysfunction of vital organs such as the brain, kidneys, liver, and lungs. This can result in respiratory distress, acute kidney injury, liver dysfunction, and other complications.
Pregnancy Complications: Plasmodium falciparum infection during pregnancy can lead to adverse outcomes for both the mother and the baby, including maternal anemia, low birth weight, preterm birth, and stillbirth.
Immune Suppression: Malaria caused by Plasmodium falciparum can suppress the host immune response, making individuals more susceptible to secondary infections and reducing the effectiveness of vaccines and other immune-mediated interventions.
Long-Term Effects: Survivors of severe malaria caused by Plasmodium falciparum may experience long-term neurological sequelae such as cognitive impairment, epilepsy, and developmental delays, particularly in children who have experienced cerebral malaria.
Economic and Social Impact: Malaria caused by Plasmodium falciparum imposes a significant economic burden on affected individuals, families, and healthcare systems, particularly in endemic regions. The disease can result in lost productivity, increased healthcare costs, and reduced socioeconomic development.
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