Hypercholesterolemia: Pravastatin is indicated for the treatment of primary hypercholesterolemia (elevated levels of cholesterol in the blood) and mixed dyslipidemia (elevated levels of both cholesterol and triglycerides). It works by inhibiting the enzyme HMG-CoA reductase, which plays a key role in cholesterol synthesis in the liver. By reducing the production of cholesterol, pravastatin helps lower LDL cholesterol (often referred to as "bad" cholesterol) and total cholesterol levels in the blood.
Prevention of Cardiovascular Events: Pravastatin is used as an adjunct to dietary therapy to reduce the risk of cardiovascular events in individuals with established coronary heart disease, including those who have had a heart attack or unstable angina, and those with a history of coronary revascularization procedures such as angioplasty or coronary artery bypass grafting (CABG). By lowering cholesterol levels, pravastatin helps prevent the progression of atherosclerosis (build-up of plaque in the arteries) and reduces the risk of cardiovascular events such as heart attack, stroke, and transient ischemic attack (TIA).
Prevention of Stroke: Pravastatin may be used to reduce the risk of stroke in individuals with a history of stroke or transient ischemic attack (TIA). By lowering cholesterol levels and stabilizing atherosclerotic plaques in the arteries supplying the brain, pravastatin helps reduce the risk of recurrent stroke.
Peripheral Arterial Disease (PAD): Pravastatin is sometimes prescribed to individuals with peripheral arterial disease, a condition characterized by narrowing of the arteries in the legs and feet due to atherosclerosis. By improving blood flow to the lower extremities and reducing the risk of blood clots, pravastatin helps alleviate symptoms such as leg pain and cramping during physical activity.
Diabetes: Pravastatin may be beneficial for individuals with diabetes, particularly those with dyslipidemia and other cardiovascular risk factors. By improving lipid profiles and reducing the risk of cardiovascular events, pravastatin contributes to the management of cardiovascular risk in diabetic patients.
Impacted of pravastatin,(prescription) On Probiotics
Rank
Probiotic
Impact
species
Escherichia coli
Reduces
Bacteria Impacted by pravastatin,(prescription)
We extend modifiers to include items that changes the parent and child taxa. I.e. for a species, that would be the genus that is belongs to and the strains in the species.
Impact of pravastatin,(prescription) on Conditions from US National Library of Medicine
A higher number indicates impact on more bacteria associated with the condition and confidence on the impact.
We have X bacteria high and Y low reported. We find that the modifier reduces some and increases other of these two groups.
We just tally: X|reduces + Y|Increase = Positive X|increases + Y|decrease = Negative.
Benefit Ratio: Numbers above 0 have increasing positive effect.
Numbers below 0 have increasing negative effect.
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