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Inflammatory Conditions: Cortisone is commonly used to manage inflammatory conditions such as arthritis, tendonitis, bursitis, and other musculoskeletal disorders. It helps reduce inflammation, swelling, pain, and stiffness associated with these conditions by suppressing the immune response and inhibiting the production of inflammatory mediators such as prostaglandins and cytokines.
Allergic Reactions: Cortisone may be used to treat allergic reactions, including allergic rhinitis, allergic conjunctivitis, contact dermatitis, and allergic asthma. It helps alleviate symptoms such as nasal congestion, sneezing, itching, redness, and wheezing by suppressing the immune response and reducing inflammation and allergic reactions in affected tissues.
Autoimmune Disorders: Cortisone is used in the management of various autoimmune disorders, including rheumatoid arthritis, systemic lupus erythematosus (SLE), inflammatory bowel disease (such as Crohn's disease and ulcerative colitis), and autoimmune hepatitis. It helps suppress the abnormal immune response and reduce inflammation and tissue damage associated with these conditions, thereby alleviating symptoms and improving quality of life.
Skin Conditions: Cortisone may be used topically or systemically to treat certain skin conditions such as eczema, psoriasis, dermatitis, and allergic skin reactions. Topical cortisone formulations, such as creams, ointments, or lotions, are applied directly to the affected skin areas to reduce inflammation, itching, redness, and scaling. Systemic cortisone may be prescribed for severe or widespread skin conditions that do not respond adequately to topical therapy.
Respiratory Conditions: Cortisone is used in the management of various respiratory conditions, including asthma, chronic obstructive pulmonary disease (COPD), and allergic rhinitis. It helps reduce airway inflammation, bronchial hyperresponsiveness, and mucus production, thereby improving lung function and relieving symptoms such as coughing, wheezing, shortness of breath, and nasal congestion.
Dosage and Administration: Cortisone is available in various formulations, including oral tablets, injections, topical creams or ointments, inhalers, and eye drops. The dosage and duration of cortisone therapy depend on factors such as the specific medical condition being treated, the severity of symptoms, the patient's response to treatment, and any underlying health conditions. Cortisone is typically used at the lowest effective dose for the shortest duration necessary to achieve therapeutic goals while minimizing the risk of adverse effects.
Side Effects: Cortisone therapy may be associated with a range of potential side effects, particularly with long-term or high-dose use. Common side effects may include weight gain, fluid retention, increased appetite, mood changes, insomnia, gastrointestinal upset, acne, skin thinning, easy bruising, and increased susceptibility to infections. Long-term cortisone use may also be associated with more serious side effects, including osteoporosis, diabetes, hypertension, cataracts, glaucoma, adrenal suppression, and increased risk of opportunistic infections.
Contraindications and Precautions: Cortisone is contraindicated in individuals with known hypersensitivity to corticosteroids or any of their components. It should be used with caution in patients with certain medical conditions, including diabetes, hypertension, osteoporosis, peptic ulcer disease, psychiatric disorders, and infections. Cortisone therapy should be tapered gradually when discontinuing treatment to avoid adrenal insufficiency or withdrawal symptoms.
We extend modifiers to include items that changes the parent and child taxa. I.e. for a species, that would be the genus that is belongs to and the strains in the species.
A higher number indicates impact on more bacteria associated with the condition and confidence on the impact.
We have X bacteria high and Y low reported. We find that the modifier reduces some and increases other of these two groups. We just tally: X|reduces + Y|Increase = Positive β X|increases + Y|decrease = Negative.
Benefit Ratio:
Numbers above 0 have increasing positive effect.
Numbers below 0 have increasing negative effect.