AI Engines For more Details: Perplexity Kagi Labs You
Lowering Blood Pressure: Labetalol works by blocking both beta receptors and alpha receptors. By doing so, it reduces the force and rate of heart contractions, as well as dilates blood vessels, leading to decreased blood pressure. Controlling hypertension with labetalol helps reduce the risk of cardiovascular events such as stroke, heart attack, and heart failure.
Management of Hypertensive Emergencies: Labetalol is often used in the management of hypertensive emergencies, where blood pressure is severely elevated and requires rapid reduction to prevent organ damage. Its dual action on both alpha and beta receptors makes it effective in quickly lowering blood pressure in these critical situations.
Angina Pectoris: Labetalol may also be used in the treatment of angina pectoris, a condition characterized by chest pain or discomfort caused by reduced blood flow to the heart muscle. By reducing the heart's workload and oxygen demand, labetalol helps alleviate symptoms of angina and improves exercise tolerance.
Heart Failure: In some cases, labetalol may be prescribed as adjunctive therapy in the management of heart failure. By reducing the heart's workload and improving cardiac output, labetalol can help alleviate symptoms and improve quality of life in patients with heart failure.
Atrial Fibrillation: Labetalol may be used to control heart rate in patients with atrial fibrillation or atrial flutter, irregular heart rhythms characterized by rapid and chaotic electrical activity in the upper chambers of the heart. By slowing down the heart rate, labetalol helps improve cardiac function and reduce symptoms associated with these arrhythmias.
Migraine Prophylaxis: Labetalol has been used off-label for the prophylactic treatment of migraine headaches. Its ability to block beta receptors may help prevent migraine attacks by stabilizing blood vessels in the brain and reducing the release of neurotransmitters involved in migraine pathophysiology.
Pheochromocytoma: Labetalol may be used to manage hypertension associated with pheochromocytoma, a rare tumor of the adrenal glands that produces excess catecholamines (adrenaline and noradrenaline). By blocking the effects of these hormones on the cardiovascular system, labetalol helps control blood pressure and stabilize the patient before surgery to remove the tumor.
| Rank | Probiotic | Impact |
|---|---|---|
| genus | Bifidobacterium | Reduces |
| species | Akkermansia muciniphila | Reduces |
| species | Bacteroides uniformis | Reduces |
| species | Bifidobacterium adolescentis | Reduces |
| species | Bifidobacterium longum | Reduces |
| species | Escherichia coli | Reduces |
| subspecies | Bifidobacterium longum subsp. infantis | Reduces |
| subspecies | Bifidobacterium longum subsp. longum | Reduces |
We extend modifiers to include items that changes the parent and child taxa. I.e. for a species, that would be the genus that is belongs to and the strains in the species.
A higher number indicates impact on more bacteria associated with the condition and confidence on the impact.
We have X bacteria high and Y low reported. We find that the modifier reduces some and increases other of these two groups. We just tally: X|reduces + Y|Increase = Positive X|increases + Y|decrease = Negative.
Benefit Ratio:
Numbers above 0 have increasing positive effect.
Numbers below 0 have increasing negative effect.
| Condition | Positive Impact | Negative Impact | Benefit Ratio Impact |
|---|---|---|---|
| Abdominal Aortic Aneurysm | 0.6 | 0.6 | |
| Acne | 0.6 | 0.3 | 1 |
| ADHD | 4.6 | 0.9 | 4.11 |
| Age-Related Macular Degeneration and Glaucoma | 1.1 | 0.4 | 1.75 |
| Allergic Rhinitis (Hay Fever) | 3 | 3.1 | -0.03 |
| Allergies | 6.9 | 4.3 | 0.6 |
| Allergy to milk products | 2.2 | 1.6 | 0.38 |
| Alopecia (Hair Loss) | 1 | 1 | |
| Alzheimer's disease | 6.1 | 6.2 | -0.02 |
| Amyotrophic lateral sclerosis (ALS) Motor Neuron | 4 | 1.7 | 1.35 |
| Ankylosing spondylitis | 3.8 | 1.1 | 2.45 |
| Anorexia Nervosa | 1.6 | 2.9 | -0.81 |
| Antiphospholipid syndrome (APS) | 1.6 | 0.3 | 4.33 |
| Asthma | 5 | 2.8 | 0.79 |
| Atherosclerosis | 1.9 | 2.1 | -0.11 |
| Atrial fibrillation | 3.7 | 2.4 | 0.54 |
| Autism | 8.1 | 8.6 | -0.06 |
| Autoimmune Disease | 1.2 | 1 | 0.2 |
| Barrett esophagus cancer | 0.3 | 0.3 | 0 |
| benign prostatic hyperplasia | 0.6 | 0.3 | 1 |
| Biofilm | 1.9 | 1.9 | |
| Bipolar Disorder | 2.4 | 1.7 | 0.41 |
| Brain Trauma | 0.9 | 1.4 | -0.56 |
| Breast Cancer | 1 | 0.3 | 2.33 |
| Cancer (General) | 0.6 | 2.2 | -2.67 |
| Carcinoma | 4.3 | 2.6 | 0.65 |
| Celiac Disease | 2.5 | 4 | -0.6 |
| Cerebral Palsy | 1.5 | 1.3 | 0.15 |
| Chronic Fatigue Syndrome | 4.2 | 5.3 | -0.26 |
| Chronic Kidney Disease | 3.7 | 2.3 | 0.61 |
| Chronic Lyme | 0.4 | 0.8 | -1 |
| Chronic Obstructive Pulmonary Disease (COPD) | 2.1 | 1.7 | 0.24 |
| Chronic Urticaria (Hives) | 1.8 | 0.7 | 1.57 |
| Coagulation / Micro clot triggering bacteria | 1.8 | 1.3 | 0.38 |
| Cognitive Function | 3.9 | 1.6 | 1.44 |
| Colorectal Cancer | 7.7 | 3.1 | 1.48 |
| Constipation | 2 | 1.6 | 0.25 |
| Coronary artery disease | 2.5 | 2.5 | 0 |
| COVID-19 | 8.8 | 10 | -0.14 |
| Crohn's Disease | 6.8 | 5.3 | 0.28 |
| Cushing's Syndrome (hypercortisolism) | 0.4 | -0.4 | |
| cystic fibrosis | 1.1 | 1.9 | -0.73 |
| d-lactic acidosis (one form of brain fog) | 0.5 | 0.5 | |
| deep vein thrombosis | 2.7 | 1.4 | 0.93 |
| Denture Wearers Oral Shifts | 1 | 1 | |
| Depression | 9.8 | 9.5 | 0.03 |
| Dermatomyositis | 0.3 | 0.3 | 0 |
| Eczema | 1.6 | 2.3 | -0.44 |
| Endometriosis | 3.4 | 2.5 | 0.36 |
| Eosinophilic Esophagitis | 0.6 | -0.6 | |
| Epilepsy | 3.1 | 1.9 | 0.63 |
| erectile dysfunction | 1.5 | 0.3 | 4 |
| Fibromyalgia | 2.9 | 2.7 | 0.07 |
| Functional constipation / chronic idiopathic constipation | 5.6 | 3.1 | 0.81 |
| gallstone disease (gsd) | 3.5 | 1 | 2.5 |
| Gastroesophageal reflux disease (Gerd) including Barrett's esophagus | 0.6 | 1.2 | -1 |
| Generalized anxiety disorder | 2.8 | 2.7 | 0.04 |
| giant cell arteritis | 0.2 | -0.2 | |
| Glioblastoma | 0.3 | -0.3 | |
| Gout | 1.9 | 1.5 | 0.27 |
| Graves' disease | 1.9 | 3.3 | -0.74 |
| Gulf War Syndrome | 0.9 | 1.3 | -0.44 |
| Halitosis | 0.9 | 0.3 | 2 |
| Hashimoto's thyroiditis | 2.8 | 1.3 | 1.15 |
| Heart Failure | 4.2 | 2.2 | 0.91 |
| hemorrhagic stroke | 1 | 1 | |
| Hidradenitis Suppurativa | 1.2 | 0.3 | 3 |
| High Histamine/low DAO | 1.5 | 0.6 | 1.5 |
| hypercholesterolemia (High Cholesterol) | 1 | 0.4 | 1.5 |
| hyperglycemia | 2.4 | 1.7 | 0.41 |
| Hyperlipidemia (High Blood Fats) | 1 | 0.3 | 2.33 |
| hypersomnia | 0.7 | -0.7 | |
| hypertension (High Blood Pressure | 4.2 | 5.3 | -0.26 |
| Hypothyroidism | 1.1 | 1 | 0.1 |
| Hypoxia | 3.3 | 0.4 | 7.25 |
| IgA nephropathy (IgAN) | 1.6 | 3.6 | -1.25 |
| Inflammatory Bowel Disease | 6.4 | 9 | -0.41 |
| Insomnia | 2.3 | 3 | -0.3 |
| Intelligence | 1.7 | 0.1 | 16 |
| Intracranial aneurysms | 1.2 | 0.9 | 0.33 |
| Irritable Bowel Syndrome | 6.7 | 4.7 | 0.43 |
| ischemic stroke | 3.3 | 1.7 | 0.94 |
| Liver Cirrhosis | 7.3 | 5 | 0.46 |
| Long COVID | 5.8 | 8 | -0.38 |
| Low bone mineral density | 1.1 | -1.1 | |
| Lung Cancer | 1.2 | 1.4 | -0.17 |
| Lymphoma | 0.9 | 0.9 | |
| Mast Cell Issues / mastitis | 0.9 | 0.9 | 0 |
| ME/CFS with IBS | 0.7 | 2.3 | -2.29 |
| ME/CFS without IBS | 1.3 | 1.8 | -0.38 |
| membranous nephropathy | 0.3 | 0.3 | |
| Menopause | 1.9 | 0.7 | 1.71 |
| Metabolic Syndrome | 7.4 | 7.2 | 0.03 |
| Mood Disorders | 9.9 | 7.8 | 0.27 |
| multiple chemical sensitivity [MCS] | 0.9 | 0.1 | 8 |
| Multiple Sclerosis | 6.6 | 4.9 | 0.35 |
| Multiple system atrophy (MSA) | 1.4 | 0.7 | 1 |
| myasthenia gravis | 0.9 | 0.7 | 0.29 |
| neuropathic pain | 0.3 | 2.6 | -7.67 |
| Neuropathy (all types) | 0.9 | 2.7 | -2 |
| neuropsychiatric disorders (PANDAS, PANS) | 1 | 1 | |
| Nonalcoholic Fatty Liver Disease (nafld) Nonalcoholic | 4.9 | 5.2 | -0.06 |
| NonCeliac Gluten Sensitivity | 1.6 | 0.6 | 1.67 |
| Obesity | 9.4 | 7.4 | 0.27 |
| obsessive-compulsive disorder | 4.9 | 3.2 | 0.53 |
| Osteoarthritis | 2.2 | 1.3 | 0.69 |
| Osteoporosis | 2.9 | 1.9 | 0.53 |
| pancreatic cancer | 1.5 | 0.6 | 1.5 |
| Parkinson's Disease | 8.7 | 6.5 | 0.34 |
| Polycystic ovary syndrome | 5 | 3.2 | 0.56 |
| Postural orthostatic tachycardia syndrome | 0.2 | 0.6 | -2 |
| Premenstrual dysphoric disorder | 0.7 | 0.4 | 0.75 |
| primary biliary cholangitis | 1.2 | 1 | 0.2 |
| Primary sclerosing cholangitis | 2.7 | 2.2 | 0.23 |
| Psoriasis | 3.6 | 2.5 | 0.44 |
| rheumatoid arthritis (RA),Spondyloarthritis (SpA) | 7.6 | 3.8 | 1 |
| Rosacea | 0.6 | 1 | -0.67 |
| Schizophrenia | 7.3 | 3.2 | 1.28 |
| scoliosis | 0.8 | 1 | -0.25 |
| Sjögren syndrome | 2.7 | 2.8 | -0.04 |
| Sleep Apnea | 1.9 | 1.8 | 0.06 |
| Slow gastric motility / Gastroparesis | 1.3 | 0.3 | 3.33 |
| Small Intestinal Bacterial Overgrowth (SIBO) | 1.8 | 0.7 | 1.57 |
| Stress / posttraumatic stress disorder | 3 | 2.8 | 0.07 |
| Systemic Lupus Erythematosus | 3.8 | 1.8 | 1.11 |
| Tic Disorder | 1 | 1.3 | -0.3 |
| Tourette syndrome | 1 | 0.3 | 2.33 |
| Type 1 Diabetes | 4.3 | 3.9 | 0.1 |
| Type 2 Diabetes | 7.8 | 7 | 0.11 |
| Ulcerative colitis | 5.3 | 6.7 | -0.26 |
| Unhealthy Ageing | 3.5 | 2.4 | 0.46 |
| Vitiligo | 2.1 | 1.7 | 0.24 |
