Blood Glucose Control: Glibenclamide helps lower blood sugar levels by increasing insulin secretion from the pancreas and improving insulin sensitivity in the body's cells. It is effective in managing hyperglycemia (high blood sugar) in patients with type 2 diabetes mellitus.
Insulin Secretagogue: As a sulfonylurea, glibenclamide acts as an insulin secretagogue, promoting the release of insulin from the beta cells of the pancreas. This mechanism helps reduce blood glucose levels by increasing insulin availability.
Hypoglycemia: One of the common side effects of glibenclamide is hypoglycemia, or low blood sugar levels. This can occur if the dose of glibenclamide is too high relative to the individual's insulin needs or if meals are skipped or delayed.
Weight Gain: Some individuals may experience weight gain while taking glibenclamide. This can be attributed to the medication's effect of increasing insulin levels, which can promote fat storage.
Gastrointestinal Effects: Glibenclamide may cause gastrointestinal side effects such as nausea, vomiting, diarrhea, or abdominal discomfort in some patients. These effects are usually mild and transient.
Skin Reactions: Rarely, glibenclamide may cause skin reactions such as rash or itching. If these symptoms occur, patients should consult their healthcare provider.
Liver Function: Glibenclamide can affect liver function, although significant liver toxicity is rare. Liver function tests may be monitored periodically in patients taking glibenclamide, especially those with pre-existing liver conditions.
Allergic Reactions: Some individuals may experience allergic reactions to glibenclamide, although these are rare. Symptoms of an allergic reaction may include rash, itching, swelling, dizziness, or difficulty breathing. Immediate medical attention is necessary if an allergic reaction occurs.
Drug Interactions: Glibenclamide may interact with other medications, including other antidiabetic drugs, leading to changes in blood sugar levels or an increased risk of hypoglycemia or other adverse effects. It's important for patients to inform their healthcare providers about all medications they are taking.
Cardiovascular Effects: While glibenclamide itself does not directly affect the cardiovascular system, maintaining good blood sugar control with medications like glibenclamide can reduce the risk of long-term cardiovascular complications associated with diabetes, such as heart disease and stroke.
We extend modifiers to include items that changes the parent and child taxa. I.e. for a species, that would be the genus that is belongs to and the strains in the species.
Impact of glibenclamide,(prescription) on Conditions from US National Library of Medicine
A higher number indicates impact on more bacteria associated with the condition and confidence on the impact.
We have X bacteria high and Y low reported. We find that the modifier reduces some and increases other of these two groups.
We just tally: X|reduces + Y|Increase = Positive β X|increases + Y|decrease = Negative.
Benefit Ratio: Numbers above 0 have increasing positive effect.
Numbers below 0 have increasing negative effect.
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