Maprotiline hydrochloride belongs to the class of tricyclic antidepressants (TCAs) and is used to alleviate symptoms of depression, including sadness, loss of interest or pleasure, changes in appetite or weight, sleep disturbances, fatigue, feelings of guilt or worthlessness, and difficulty concentrating.
Mechanism of Action:
It works by inhibiting the reuptake of neurotransmitters such as serotonin and norepinephrine in the brain, thereby increasing their levels and restoring chemical balance, which can improve mood and alleviate depressive symptoms.
Dosage and Administration:
Maprotiline hydrochloride is typically administered orally in the form of tablets or capsules.
The dosage prescribed depends on the severity of depression, individual response to the medication, and other factors such as age and medical history.
It is usually taken once daily, preferably at bedtime, to minimize potential side effects such as drowsiness.
Side Effects:
Common side effects of maprotiline hydrochloride may include drowsiness, dizziness, blurred vision, dry mouth, constipation, urinary retention, increased heart rate, weight gain, and sexual dysfunction.
Some individuals may experience more serious side effects such as orthostatic hypotension (drop in blood pressure upon standing), arrhythmias, seizures, and allergic reactions.
Precautions:
Maprotiline hydrochloride should be used with caution in patients with a history of seizures, cardiac disorders, urinary retention, glaucoma, or liver disease.
It is not recommended for use in individuals with a known hypersensitivity to maprotiline or other TCAs.
Abrupt discontinuation of maprotiline therapy should be avoided to prevent withdrawal symptoms.
Pregnancy and Lactation:
The safety of maprotiline hydrochloride during pregnancy and lactation has not been well established. Pregnant or breastfeeding women should consult their healthcare provider before using this medication.
Interactions:
Maprotiline hydrochloride may interact with other medications, including monoamine oxidase inhibitors (MAOIs), selective serotonin reuptake inhibitors (SSRIs), anticholinergic drugs, and certain cardiovascular medications, leading to potentially serious complications.
Patients should inform their healthcare provider about all medications, supplements, and herbal products they are taking before starting maprotiline therapy.
Monitoring:
Patients taking maprotiline hydrochloride should be closely monitored for therapeutic response and any adverse effects. Dosage adjustments may be necessary based on individual response and tolerability.
Bacteria Impacted by maprotiline hydrochloride,(prescription)
We extend modifiers to include items that changes the parent and child taxa. I.e. for a species, that would be the genus that is belongs to and the strains in the species.
Impact of maprotiline hydrochloride,(prescription) on Conditions from US National Library of Medicine
A higher number indicates impact on more bacteria associated with the condition and confidence on the impact.
We have X bacteria high and Y low reported. We find that the modifier reduces some and increases other of these two groups.
We just tally: X|reduces + Y|Increase = Positive β X|increases + Y|decrease = Negative.
Benefit Ratio: Numbers above 0 have increasing positive effect.
Numbers below 0 have increasing negative effect.
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