AI Engines For more Details: Perplexity Kagi Labs You
Local Anesthesia: Procaine hydrochloride acts as a local anesthetic by blocking the transmission of nerve impulses, thereby inhibiting the sensation of pain in a specific area of the body where it is applied or injected. It works by reversibly inhibiting the function of voltage-gated sodium channels in nerve cell membranes, preventing the generation and propagation of action potentials.
Dental Procedures: Procaine hydrochloride is frequently used by dentists for local anesthesia during dental procedures, such as tooth extractions, fillings, root canals, and gum surgeries. It is administered via injection into the soft tissues surrounding the treatment area to numb the nerves and alleviate pain.
Minor Surgical Procedures: Procaine hydrochloride may also be used for local anesthesia during minor surgical procedures, dermatological procedures, and medical interventions that require pain control in a specific region of the body. It is commonly used in outpatient settings and medical offices for procedures such as skin biopsies, suturing of wounds, and removal of skin lesions.
Onset and Duration of Action: The onset of action of procaine hydrochloride typically occurs within a few minutes after administration, with the peak effect reached within 5 to 10 minutes. The duration of anesthesia varies depending on factors such as the concentration of the procaine solution, the volume injected, and the vascularity of the tissues. Generally, the effects of procaine last for approximately 30 minutes to one hour.
Adverse Effects: While procaine hydrochloride is generally considered safe when used appropriately, it may cause certain adverse effects, particularly if administered incorrectly or in excessive doses. Common side effects may include local reactions at the injection site, such as pain, swelling, bruising, and redness. In rare cases, allergic reactions, including anaphylaxis, may occur, especially in individuals with a history of hypersensitivity to local anesthetics.
Precautions: Procaine hydrochloride should be used with caution in patients with a known allergy to local anesthetics, as well as those with certain medical conditions such as cardiovascular disease, epilepsy, or myasthenia gravis. Careful aspiration prior to injection and slow, incremental administration of the drug can help minimize the risk of inadvertent intravascular injection and systemic toxicity.
Contraindications: Procaine hydrochloride is contraindicated in patients with a history of severe allergic reactions to local anesthetics, as well as those with certain medical conditions that may increase the risk of adverse effects or complications. It should not be used in regions of infection or inflammation, and caution should be exercised when administering it near major nerves or blood vessels.
| Rank | Probiotic | Impact |
|---|---|---|
| species | Akkermansia muciniphila | Reduces |
| species | Lacticaseibacillus paracasei | Reduces |
We extend modifiers to include items that changes the parent and child taxa. I.e. for a species, that would be the genus that is belongs to and the strains in the species.
A higher number indicates impact on more bacteria associated with the condition and confidence on the impact.
We have X bacteria high and Y low reported. We find that the modifier reduces some and increases other of these two groups. We just tally: X|reduces + Y|Increase = Positive X|increases + Y|decrease = Negative.
Benefit Ratio:
Numbers above 0 have increasing positive effect.
Numbers below 0 have increasing negative effect.
| Condition | Positive Impact | Negative Impact | Benefit Ratio Impact |
|---|---|---|---|
| Acne | 0.1 | -0.1 | |
| Allergic Rhinitis (Hay Fever) | 0 | 0 | |
| Allergies | 0 | 0.1 | 0 |
| Allergy to milk products | 0 | 0 | |
| Alzheimer's disease | 0.1 | 0.1 | 0 |
| Amyotrophic lateral sclerosis (ALS) Motor Neuron | 0.1 | 0 | 0 |
| Ankylosing spondylitis | 0 | 0 | |
| Asthma | 0.1 | -0.1 | |
| Atherosclerosis | 1 | 0 | 0 |
| Autism | 0.2 | 0.6 | -2 |
| Biofilm | 0.5 | 0.5 | |
| Brain Trauma | 0.5 | 0.5 | |
| Breast Cancer | 0.5 | -0.5 | |
| Cancer (General) | 0.6 | -0.6 | |
| Celiac Disease | 0 | 0 | |
| Cerebral Palsy | 0 | 0 | |
| Chronic Fatigue Syndrome | 0 | 0 | |
| Chronic Kidney Disease | 0.1 | 0.1 | 0 |
| Chronic Urticaria (Hives) | 0 | 0 | |
| Colorectal Cancer | 1.1 | 0 | 0 |
| COVID-19 | 0 | 0.1 | 0 |
| Crohn's Disease | 0.5 | 0.1 | 4 |
| deep vein thrombosis | 0.5 | 0.5 | |
| Depression | 1.2 | 1.2 | 0 |
| Epilepsy | 0 | 0.1 | 0 |
| Functional constipation / chronic idiopathic constipation | 0.1 | -0.1 | |
| gallstone disease (gsd) | 0.5 | 0 | 0 |
| Generalized anxiety disorder | 0 | 0 | 0 |
| Gout | 0 | 0 | 0 |
| Gulf War Syndrome | 0.1 | -0.1 | |
| Hashimoto's thyroiditis | 0.1 | 0.1 | 0 |
| Heart Failure | 0 | 0 | |
| Hidradenitis Suppurativa | 0.5 | 0.5 | |
| High Histamine/low DAO | 1.3 | 1.3 | |
| hypercholesterolemia (High Cholesterol) | 0 | 0 | |
| hyperglycemia | 0.6 | 0.1 | 5 |
| Hyperlipidemia (High Blood Fats) | 0 | 0 | |
| hypertension (High Blood Pressure | 0.2 | 0 | 0 |
| Hypothyroidism | 0.5 | 0.5 | |
| Hypoxia | 0 | 0 | |
| Inflammatory Bowel Disease | 0.5 | 0.1 | 4 |
| Insomnia | 0.1 | -0.1 | |
| Irritable Bowel Syndrome | 0.7 | 0.1 | 6 |
| ischemic stroke | 0 | 0 | |
| Liver Cirrhosis | 0 | 0.7 | 0 |
| Long COVID | 0.5 | 0 | 0 |
| Lung Cancer | 0 | 0 | |
| Menopause | 0 | 0 | |
| Metabolic Syndrome | 0 | 0.1 | 0 |
| Mood Disorders | 1.2 | 0.6 | 1 |
| multiple chemical sensitivity [MCS] | 0 | 0 | |
| Multiple Sclerosis | 0.1 | 0.1 | |
| Multiple system atrophy (MSA) | 0.1 | 0.1 | |
| neuropathic pain | 0 | 0 | |
| Neuropathy (all types) | 0 | 0 | |
| Nonalcoholic Fatty Liver Disease (nafld) Nonalcoholic | 0.6 | -0.6 | |
| NonCeliac Gluten Sensitivity | 0 | 0 | |
| Obesity | 1.3 | 1.2 | 0.08 |
| obsessive-compulsive disorder | 0.2 | -0.2 | |
| Osteoarthritis | 0 | 0 | |
| Osteoporosis | 0 | 0 | |
| Parkinson's Disease | 1.8 | 0 | 0 |
| Polycystic ovary syndrome | 0 | 0 | |
| Primary sclerosing cholangitis | 0.5 | 0.5 | |
| Psoriasis | 0 | 0 | 0 |
| rheumatoid arthritis (RA),Spondyloarthritis (SpA) | 1.1 | 1.1 | |
| Rosacea | 0.1 | 0.1 | |
| Schizophrenia | 0 | 0 | 0 |
| scoliosis | 0.5 | 0.5 | |
| sensorineural hearing loss | 0.5 | 0.5 | |
| Small Intestinal Bacterial Overgrowth (SIBO) | 0.5 | 0.5 | |
| Stress / posttraumatic stress disorder | 0 | 0 | 0 |
| Systemic Lupus Erythematosus | 0 | 0 | |
| Tourette syndrome | 0 | 0 | |
| Type 1 Diabetes | 0 | 0 | |
| Type 2 Diabetes | 0 | 0.1 | 0 |
| Ulcerative colitis | 0.5 | 0.1 | 4 |
| Unhealthy Ageing | 0.1 | 0 | 0 |
| Vitiligo | 0 | 0 |
