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Peripheral Vascular Diseases: Buflomedil hydrochloride is indicated for the treatment of peripheral arterial occlusive diseases (PAOD) and intermittent claudication. It works by dilating blood vessels, particularly arterioles and capillaries, thereby improving blood circulation to the limbs. This can help alleviate symptoms such as pain, cramping, and weakness during physical activity.
Intermittent Claudication: Intermittent claudication is a symptom of peripheral arterial disease characterized by pain or cramping in the legs during physical activity due to inadequate blood flow. Buflomedil hydrochloride helps increase blood flow to the affected limbs, reducing symptoms and improving exercise tolerance in individuals with intermittent claudication.
Vasodilation: Buflomedil hydrochloride exerts its therapeutic effects by acting as a vasodilator, relaxing smooth muscle cells in blood vessel walls and widening the diameter of blood vessels. This vasodilatory action enhances blood flow and oxygen delivery to tissues, particularly in areas with impaired circulation.
Tissue Oxygenation: By improving blood flow and oxygen delivery to peripheral tissues, buflomedil hydrochloride may help promote tissue healing and reduce the risk of complications associated with peripheral vascular diseases, such as ischemic ulcers and gangrene.
Symptom Relief: Buflomedil hydrochloride can alleviate symptoms associated with peripheral vascular diseases, including leg pain, numbness, tingling, and cold extremities. By enhancing blood flow, it may improve patients' quality of life and functional status.
Adverse Effects: Common side effects of buflomedil hydrochloride may include gastrointestinal disturbances (e.g., nausea, vomiting, diarrhea), headache, dizziness, flushing, and palpitations. These side effects are usually mild and transient.
Contraindications: Buflomedil hydrochloride is contraindicated in patients with hypersensitivity to the drug or its components. It should be used with caution in individuals with severe hepatic impairment, as hepatic metabolism plays a role in the elimination of buflomedil.
Drug Interactions: Buflomedil hydrochloride may interact with other medications, including antihypertensive agents and vasodilators, potentially leading to additive hypotensive effects. Healthcare providers should review patients' medication regimens to minimize the risk of drug interactions.
Pregnancy and Lactation: The safety of buflomedil hydrochloride during pregnancy and breastfeeding has not been established. It should only be used in pregnant or lactating women if the potential benefits outweigh the risks and under the supervision of a healthcare provider.
We extend modifiers to include items that changes the parent and child taxa. I.e. for a species, that would be the genus that is belongs to and the strains in the species.
A higher number indicates impact on more bacteria associated with the condition and confidence on the impact.
We have X bacteria high and Y low reported. We find that the modifier reduces some and increases other of these two groups. We just tally: X|reduces + Y|Increase = Positive β X|increases + Y|decrease = Negative.
Benefit Ratio:
Numbers above 0 have increasing positive effect.
Numbers below 0 have increasing negative effect.