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Antiemetic Effects: Bromopride acts as an antiemetic, meaning it helps prevent or reduce nausea and vomiting. It works by blocking dopamine receptors in the chemoreceptor trigger zone (CTZ) of the brain and in the gastrointestinal tract, thereby reducing the sensitivity of these areas to stimuli that trigger nausea and vomiting.
Gastric Motility: Bromopride also has prokinetic properties, which means it enhances gastrointestinal motility. By stimulating the release of acetylcholine, it increases the contraction of smooth muscles in the stomach and intestines, thereby promoting gastric emptying and improving symptoms of dyspepsia, gastroesophageal reflux disease (GERD), and other gastrointestinal disorders.
Indications: Bromopride is commonly prescribed for the treatment of various gastrointestinal conditions, including functional dyspepsia, gastroparesis, gastroesophageal reflux, nausea and vomiting associated with chemotherapy, postoperative nausea and vomiting, and motion sickness.
Side Effects: While bromopride is generally well-tolerated, it may cause side effects in some individuals. Common side effects include drowsiness, dizziness, headache, dry mouth, constipation, and diarrhea. These side effects are usually mild and transient.
Extrapyramidal Symptoms (EPS): Like other medications that block dopamine receptors, bromopride may rarely cause extrapyramidal symptoms (EPS) such as dystonia, akathisia, parkinsonism, and tardive dyskinesia. These symptoms are more likely to occur at higher doses or with long-term use, and they may require discontinuation of the medication or additional treatment.
Cardiovascular Effects: Bromopride has been associated with a rare but serious side effect called QT prolongation, which can increase the risk of ventricular arrhythmias, including torsades de pointes. It should be used with caution in individuals with preexisting cardiovascular conditions or those taking other medications that can prolong the QT interval.
Allergic Reactions: Allergic reactions to bromopride are rare but can occur. Signs of an allergic reaction may include rash, itching, swelling of the face or throat, severe dizziness, or difficulty breathing. If any of these symptoms occur, medical attention should be sought immediately.
Drug Interactions: Bromopride may interact with other medications, particularly those that affect dopamine levels or prolong the QT interval. It is essential to inform healthcare providers about all medications, supplements, and herbal products being taken to avoid potential interactions.
We extend modifiers to include items that changes the parent and child taxa. I.e. for a species, that would be the genus that is belongs to and the strains in the species.
A higher number indicates impact on more bacteria associated with the condition and confidence on the impact.
We have X bacteria high and Y low reported. We find that the modifier reduces some and increases other of these two groups. We just tally: X|reduces + Y|Increase = Positive X|increases + Y|decrease = Negative.
Benefit Ratio:
Numbers above 0 have increasing positive effect.
Numbers below 0 have increasing negative effect.
