AI Engines For more Details: Perplexity Kagi Labs You
Treatment of Folate Deficiency: Folinic acid is used to treat folate deficiency, which can occur due to inadequate dietary intake, malabsorption disorders, certain medications, or increased demand during pregnancy or certain medical conditions.
Supports DNA Synthesis and Repair: Folinic acid plays a crucial role in DNA synthesis and repair. It serves as a cofactor in various enzymatic reactions involved in the production of nucleic acids, which are essential for cell division and growth.
Management of Megaloblastic Anemia: Folinic acid supplementation can help in the management of megaloblastic anemia, a condition characterized by abnormally large and immature red blood cells due to impaired DNA synthesis. Megaloblastic anemia is commonly caused by folate deficiency or vitamin B12 deficiency.
Adjunct Therapy in Cancer Treatment: Folinic acid is often used as an adjunct therapy in combination with certain chemotherapy drugs, such as methotrexate. It helps reduce the toxic effects of methotrexate on normal cells by "rescuing" them from the inhibition of dihydrofolate reductase caused by methotrexate.
Neurological Disorders: Folinic acid may be used as part of the treatment regimen for certain neurological disorders, including cerebral folate deficiency syndrome and autism spectrum disorders (ASD). Some studies suggest that folinic acid supplementation may improve certain neurological symptoms in these conditions.
Prevention of Neural Tube Defects: Adequate folate intake, including folinic acid supplementation, is essential during pregnancy to reduce the risk of neural tube defects, such as spina bifida and anencephaly, in the developing fetus.
Management of Methotrexate Toxicity: Folinic acid is also used as a rescue therapy to mitigate the toxic effects of high-dose methotrexate chemotherapy, which can lead to severe bone marrow suppression and mucositis. Folinic acid helps "rescue" normal cells from the effects of methotrexate by providing an alternative pathway for folic acid metabolism.
Administration Routes: Folinic acid can be administered orally, intravenously, or intramuscularly, depending on the indication and the patient's clinical condition.
Side Effects and Adverse Reactions: Folinic acid is generally well-tolerated, but some individuals may experience side effects such as nausea, vomiting, diarrhea, rash, or allergic reactions. Rarely, high doses of folinic acid may lead to electrolyte imbalances or exacerbate seizures in individuals with epilepsy.
Monitoring and Dosage Adjustments: Patients receiving folinic acid therapy may require monitoring of folate levels in the blood and adjustment of dosage based on clinical response and laboratory parameters.
| Rank | Probiotic | Impact |
|---|---|---|
| genus | Bifidobacterium | Reduces |
| species | Bifidobacterium longum | Reduces |
| species | Escherichia coli | Reduces |
| subspecies | Bifidobacterium longum subsp. infantis | Reduces |
| subspecies | Bifidobacterium longum subsp. longum | Reduces |
We extend modifiers to include items that changes the parent and child taxa. I.e. for a species, that would be the genus that is belongs to and the strains in the species.
A higher number indicates impact on more bacteria associated with the condition and confidence on the impact.
We have X bacteria high and Y low reported. We find that the modifier reduces some and increases other of these two groups. We just tally: X|reduces + Y|Increase = Positive X|increases + Y|decrease = Negative.
Benefit Ratio:
Numbers above 0 have increasing positive effect.
Numbers below 0 have increasing negative effect.
| Condition | Positive Impact | Negative Impact | Benefit Ratio Impact |
|---|---|---|---|
| Abdominal Aortic Aneurysm | 0 | 0 | |
| Acne | 0.3 | -0.3 | |
| ADHD | 1.1 | 0.3 | 2.67 |
| Allergic Rhinitis (Hay Fever) | 1.5 | 0.8 | 0.88 |
| Allergies | 1.6 | 1.1 | 0.45 |
| Allergy to milk products | 1.3 | 1.2 | 0.08 |
| Alopecia (Hair Loss) | 0.3 | 0.3 | |
| Alzheimer's disease | 2 | 2.2 | -0.1 |
| Amyotrophic lateral sclerosis (ALS) Motor Neuron | 1.3 | 0.4 | 2.25 |
| Ankylosing spondylitis | 1.9 | 0.6 | 2.17 |
| Anorexia Nervosa | 0.9 | 1 | -0.11 |
| Antiphospholipid syndrome (APS) | 0.5 | 0.5 | |
| Asthma | 1.2 | 0.9 | 0.33 |
| Atherosclerosis | 1.4 | 1.4 | |
| Atrial fibrillation | 1.6 | 1.2 | 0.33 |
| Autism | 2.7 | 2.6 | 0.04 |
| Autoimmune Disease | 1.2 | 0.3 | 3 |
| Barrett esophagus cancer | 0.3 | -0.3 | |
| benign prostatic hyperplasia | 0.6 | 0.3 | 1 |
| Biofilm | 0.4 | 0.4 | |
| Bipolar Disorder | 1.2 | 0.6 | 1 |
| Brain Trauma | 0.9 | 0.9 | 0 |
| Breast Cancer | 0.1 | 0.1 | |
| Cancer (General) | 0.4 | -0.4 | |
| Carcinoma | 2 | 1.2 | 0.67 |
| Celiac Disease | 1 | 1 | 0 |
| Cerebral Palsy | 0.9 | 0.6 | 0.5 |
| Chronic Fatigue Syndrome | 1.6 | 1.8 | -0.13 |
| Chronic Kidney Disease | 1.2 | 0.6 | 1 |
| Chronic Lyme | 0.3 | -0.3 | |
| Chronic Obstructive Pulmonary Disease (COPD) | 0.7 | 0.6 | 0.17 |
| Chronic Urticaria (Hives) | 1 | 0.2 | 4 |
| Coagulation / Micro clot triggering bacteria | 1 | 0.6 | 0.67 |
| Cognitive Function | 1.5 | 0.6 | 1.5 |
| Colorectal Cancer | 2.5 | 1.3 | 0.92 |
| Constipation | 1.4 | 1.4 | |
| Coronary artery disease | 1.6 | 0.7 | 1.29 |
| COVID-19 | 2.4 | 2.3 | 0.04 |
| Crohn's Disease | 2.8 | 1.6 | 0.75 |
| Cushing's Syndrome (hypercortisolism) | 0.5 | -0.5 | |
| cystic fibrosis | 0.7 | 0.6 | 0.17 |
| d-lactic acidosis (one form of brain fog) | 0.1 | 0.1 | |
| deep vein thrombosis | 1.1 | 0.9 | 0.22 |
| Denture Wearers Oral Shifts | 0.3 | 0.3 | |
| Depression | 2.8 | 2.6 | 0.08 |
| Dermatomyositis | 0.3 | 0.3 | 0 |
| Eczema | 0.9 | 0.7 | 0.29 |
| Endometriosis | 1.9 | 0.7 | 1.71 |
| Eosinophilic Esophagitis | 0.3 | -0.3 | |
| Epilepsy | 2 | 0.6 | 2.33 |
| erectile dysfunction | 0.9 | 0.3 | 2 |
| Fibromyalgia | 0.3 | 0.8 | -1.67 |
| Functional constipation / chronic idiopathic constipation | 2.6 | 1.3 | 1 |
| gallstone disease (gsd) | 1.1 | 0.3 | 2.67 |
| Gastroesophageal reflux disease (Gerd) including Barrett's esophagus | 0.3 | 0.3 | 0 |
| Generalized anxiety disorder | 1.6 | 1.2 | 0.33 |
| Glioblastoma | 0.3 | -0.3 | |
| Gout | 0.9 | 0.3 | 2 |
| Graves' disease | 1.2 | 1.7 | -0.42 |
| Gulf War Syndrome | 0.6 | 0.4 | 0.5 |
| Halitosis | 0.6 | 0.3 | 1 |
| Hashimoto's thyroiditis | 1 | 0.6 | 0.67 |
| Heart Failure | 1.9 | 0.6 | 2.17 |
| Hidradenitis Suppurativa | 0.6 | 0.6 | |
| High Histamine/low DAO | 0.1 | 0.6 | -5 |
| hypercholesterolemia (High Cholesterol) | 0.1 | 0.1 | |
| hyperglycemia | 0.7 | 0.6 | 0.17 |
| Hyperlipidemia (High Blood Fats) | 0.6 | 0.3 | 1 |
| hypersomnia | 0.3 | -0.3 | |
| hypertension (High Blood Pressure | 2 | 1.7 | 0.18 |
| Hypothyroidism | 0.6 | -0.6 | |
| Hypoxia | 1.3 | 0.3 | 3.33 |
| IgA nephropathy (IgAN) | 0.9 | 0.5 | 0.8 |
| Inflammatory Bowel Disease | 2.3 | 2.1 | 0.1 |
| Insomnia | 0.9 | 0.9 | 0 |
| Intelligence | 0.7 | 0.1 | 6 |
| Intracranial aneurysms | 0.6 | 0.6 | 0 |
| Irritable Bowel Syndrome | 2.1 | 2 | 0.05 |
| ischemic stroke | 1.4 | 0.9 | 0.56 |
| Liver Cirrhosis | 2.3 | 1.6 | 0.44 |
| Long COVID | 2.1 | 1.8 | 0.17 |
| Low bone mineral density | 0.3 | -0.3 | |
| Lung Cancer | 0.6 | 0.3 | 1 |
| Lymphoma | 0.6 | 0.6 | |
| Mast Cell Issues / mastitis | 0.9 | 0.9 | 0 |
| ME/CFS with IBS | 0.3 | 0.7 | -1.33 |
| ME/CFS without IBS | 0.3 | 0.6 | -1 |
| membranous nephropathy | 0.3 | 0.3 | |
| Menopause | 0.5 | 0.5 | |
| Metabolic Syndrome | 2.7 | 2.2 | 0.23 |
| Mood Disorders | 2.5 | 2.6 | -0.04 |
| multiple chemical sensitivity [MCS] | 0.3 | 0.3 | |
| Multiple Sclerosis | 1.8 | 1.6 | 0.13 |
| Multiple system atrophy (MSA) | 0 | 0.6 | 0 |
| myasthenia gravis | 0.9 | 0.9 | |
| neuropathic pain | 0.7 | -0.7 | |
| Neuropathy (all types) | 0.3 | 0.6 | -1 |
| neuropsychiatric disorders (PANDAS, PANS) | 0.4 | 0.4 | |
| Nonalcoholic Fatty Liver Disease (nafld) Nonalcoholic | 2.1 | 1.2 | 0.75 |
| NonCeliac Gluten Sensitivity | 0.9 | 0.6 | 0.5 |
| Obesity | 3 | 2.4 | 0.25 |
| obsessive-compulsive disorder | 1.8 | 1.2 | 0.5 |
| Osteoarthritis | 1.2 | 1.2 | 0 |
| Osteoporosis | 1.2 | 0.6 | 1 |
| pancreatic cancer | 0.3 | 0.3 | 0 |
| Parkinson's Disease | 2.5 | 2.2 | 0.14 |
| Polycystic ovary syndrome | 2.5 | 1.3 | 0.92 |
| Postural orthostatic tachycardia syndrome | 0.6 | -0.6 | |
| Premenstrual dysphoric disorder | 0.6 | 0.6 | |
| primary biliary cholangitis | 0.3 | 0.6 | -1 |
| Primary sclerosing cholangitis | 0.6 | 0.6 | 0 |
| Psoriasis | 1.2 | 0.6 | 1 |
| rheumatoid arthritis (RA),Spondyloarthritis (SpA) | 2.7 | 1.3 | 1.08 |
| Rosacea | 0.6 | 0.6 | |
| Schizophrenia | 1.8 | 1.2 | 0.5 |
| scoliosis | 0.4 | 0.3 | 0.33 |
| Sjögren syndrome | 0.9 | 0.6 | 0.5 |
| Sleep Apnea | 0.9 | 0.9 | 0 |
| Slow gastric motility / Gastroparesis | 0.7 | 0.3 | 1.33 |
| Small Intestinal Bacterial Overgrowth (SIBO) | 1 | 0.1 | 9 |
| Stress / posttraumatic stress disorder | 0.7 | 1.2 | -0.71 |
| Systemic Lupus Erythematosus | 1.6 | 0.6 | 1.67 |
| Tic Disorder | 0.8 | 0.6 | 0.33 |
| Tourette syndrome | 0.3 | 0.3 | 0 |
| Type 1 Diabetes | 2.2 | 1.8 | 0.22 |
| Type 2 Diabetes | 3.1 | 2.3 | 0.35 |
| Ulcerative colitis | 1.9 | 1.7 | 0.12 |
| Unhealthy Ageing | 1.1 | 0.6 | 0.83 |
| Vitiligo | 1.3 | 0.4 | 2.25 |
