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Gallstone Dissolution: Ursodiol works by decreasing the production of cholesterol and by dissolving cholesterol-containing gallstones, which can help alleviate symptoms associated with gallstones and prevent complications such as gallbladder inflammation (cholecystitis) or blockage of the bile ducts.
Prevention of Gallstone Formation: Ursodiol can also be used to prevent the formation of new gallstones in patients who are at high risk, such as those who have undergone bariatric surgery or who have rapid weight loss.
Treatment of Primary Biliary Cholangitis (PBC): Ursodiol is a first-line treatment for PBC, a chronic autoimmune liver disease that damages the bile ducts in the liver. Ursodiol helps improve liver function tests and may slow the progression of the disease, although it does not cure PBC.
Side Effects: Common side effects of ursodiol may include diarrhea, upset stomach, nausea, vomiting, and abdominal pain. These side effects are usually mild and may improve over time as the body adjusts to the medication. However, if these side effects persist or worsen, it's important to consult a healthcare professional.
Contraindications: Ursodiol is contraindicated in patients with certain conditions, such as complete biliary obstruction, acute cholecystitis, and pancreatitis. It should also be used with caution in patients with liver or gallbladder disease, kidney disease, or a history of gallstones.
Monitoring: Patients taking ursodiol may require regular monitoring of liver function tests and ultrasound imaging to assess the effectiveness of treatment and to detect any potential complications.
Interactions: Ursodiol may interact with other medications, such as antacids containing aluminum, cholesterol-lowering medications (e.g., cholestyramine), and certain immunosuppressive drugs. It's important to inform your healthcare provider about all medications, supplements, and herbal products you are taking before starting ursodiol treatment.
Pregnancy and Breastfeeding: Ursodiol is generally considered safe to use during pregnancy and breastfeeding, but pregnant or breastfeeding women should consult their healthcare provider before taking any medication.
We extend modifiers to include items that changes the parent and child taxa. I.e. for a species, that would be the genus that is belongs to and the strains in the species.
A higher number indicates impact on more bacteria associated with the condition and confidence on the impact.
We have X bacteria high and Y low reported. We find that the modifier reduces some and increases other of these two groups. We just tally: X|reduces + Y|Increase = Positive β X|increases + Y|decrease = Negative.
Benefit Ratio:
Numbers above 0 have increasing positive effect.
Numbers below 0 have increasing negative effect.