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Antidepressant Effects: Mianserin is classified as a tetracyclic antidepressant (TeCA) and works by increasing the levels of serotonin and noradrenaline in the brain. These neurotransmitters are involved in regulating mood, emotions, and feelings of well-being. By enhancing their activity, mianserin helps alleviate symptoms of depression.
Treatment of Depression: Mianserin is indicated for the treatment of major depressive disorder (MDD). It may be prescribed for individuals experiencing persistent feelings of sadness, hopelessness, loss of interest or pleasure in activities, changes in appetite or weight, sleep disturbances, fatigue, feelings of worthlessness or guilt, difficulty concentrating, or suicidal thoughts.
Symptom Improvement: Mianserin helps improve depressive symptoms, including mood disturbances, anxiety, agitation, sleep disturbances, and physical symptoms such as changes in appetite or energy levels.
Onset of Action: Like other antidepressants, mianserin may take several weeks to exert its full therapeutic effects. Patients are advised to continue taking the medication as prescribed even if they do not notice immediate improvement in their symptoms.
Dosage Adjustment: The dosage of mianserin is individualized based on the patient's response to treatment and tolerability. Healthcare providers may start with a low dose and gradually increase it to achieve optimal therapeutic effects while minimizing side effects.
Side Effects: Common side effects of mianserin may include drowsiness, dizziness, dry mouth, blurred vision, constipation, increased appetite, weight gain, and sexual dysfunction. These side effects are usually mild and transient, but if they persist or worsen, patients should consult their healthcare provider.
Serotonin Syndrome: Mianserin, like other antidepressants, may rarely cause serotonin syndrome when taken in combination with other medications that increase serotonin levels, such as selective serotonin reuptake inhibitors (SSRIs), serotonin-norepinephrine reuptake inhibitors (SNRIs), or monoamine oxidase inhibitors (MAOIs). Symptoms of serotonin syndrome include agitation, hallucinations, rapid heartbeat, high blood pressure, fever, excessive sweating, tremors, muscle rigidity, and seizures. Immediate medical attention is required if these symptoms occur.
Withdrawal Symptoms: Abrupt discontinuation of mianserin may lead to withdrawal symptoms, including dizziness, nausea, headache, irritability, insomnia, and flu-like symptoms. To minimize the risk of withdrawal reactions, the dosage of mianserin should be gradually tapered under the supervision of a healthcare provider when discontinuing treatment.
Monitoring: Patients taking mianserin should be closely monitored for changes in mood, behavior, or suicidal ideation, especially when starting or adjusting the dosage of the medication. Healthcare providers may conduct regular follow-up appointments to assess treatment response and monitor for adverse effects.
Contraindications: Mianserin is contraindicated in individuals with a known hypersensitivity to the drug, as well as in patients with acute intoxication with alcohol, barbiturates, or other central nervous system depressants. Additionally, mianserin should not be used concomitantly with MAOIs or within two weeks of discontinuing MAOI therapy due to the risk of serotonin syndrome.
We extend modifiers to include items that changes the parent and child taxa. I.e. for a species, that would be the genus that is belongs to and the strains in the species.
A higher number indicates impact on more bacteria associated with the condition and confidence on the impact.
We have X bacteria high and Y low reported. We find that the modifier reduces some and increases other of these two groups. We just tally: X|reduces + Y|Increase = Positive X|increases + Y|decrease = Negative.
Benefit Ratio:
Numbers above 0 have increasing positive effect.
Numbers below 0 have increasing negative effect.
