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Analgesic Properties: Levopropoxyphene napsylate is an opioid analgesic that acts centrally to alleviate pain. It is structurally related to methadone and propoxyphene. Its analgesic effects are primarily attributed to its activity at opioid receptors in the central nervous system.
Withdrawn from Market: Levopropoxyphene-containing products, such as those containing propoxyphene or dextropropoxyphene, have been withdrawn from the market in several countries due to safety concerns. These concerns stem from reports of serious cardiac arrhythmias, including prolongation of the QT interval, torsades de pointes, and sudden cardiac death associated with propoxyphene use.
Cardiovascular Risks: Levopropoxyphene napsylate and its parent compound propoxyphene have been associated with an increased risk of cardiovascular events, particularly in patients with pre-existing cardiac conditions or those taking other medications that prolong the QT interval. This has led to regulatory actions to limit or withdraw the use of these drugs.
Respiratory Depression: Like other opioid analgesics, levopropoxyphene napsylate can cause respiratory depression, which can be life-threatening, especially in cases of overdose or when combined with other central nervous system depressants such as alcohol or benzodiazepines.
Central Nervous System Effects: Levopropoxyphene napsylate may also cause central nervous system effects such as sedation, dizziness, confusion, and impairment of cognitive and motor function.
Withdrawal Syndrome: Abrupt discontinuation of levopropoxyphene napsylate after prolonged use may lead to withdrawal symptoms, including flu-like symptoms, anxiety, agitation, insomnia, sweating, and gastrointestinal disturbances.
Risk of Addiction and Dependence: As an opioid analgesic, levopropoxyphene napsylate has the potential for abuse, addiction, and physical dependence, particularly in individuals with a history of substance abuse or addiction.
We extend modifiers to include items that changes the parent and child taxa. I.e. for a species, that would be the genus that is belongs to and the strains in the species.
A higher number indicates impact on more bacteria associated with the condition and confidence on the impact.
We have X bacteria high and Y low reported. We find that the modifier reduces some and increases other of these two groups. We just tally: X|reduces + Y|Increase = Positive β X|increases + Y|decrease = Negative.
Benefit Ratio:
Numbers above 0 have increasing positive effect.
Numbers below 0 have increasing negative effect.