Many helminth infections affect the gastrointestinal tract and can cause symptoms such as abdominal pain, diarrhea, nausea, vomiting, and loss of appetite.
Some helminths, such as roundworms (nematodes) and tapeworms (cestodes), can inhabit the intestines, leading to intestinal obstruction, malabsorption of nutrients, and weight loss.
Anemia:
Certain helminth infections, particularly those caused by blood-feeding parasites like hookworms, can lead to iron-deficiency anemia due to blood loss.
Nutritional Deficiencies:
Helminth infections can interfere with the absorption of nutrients in the intestines, leading to deficiencies in essential nutrients such as iron, vitamin B12, and folate. This can result in fatigue, weakness, and impaired growth and development, especially in children.
Allergic Reactions:
Some individuals may develop allergic reactions to helminth infections, particularly to the larvae or eggs of certain worms. Allergic responses can manifest as skin rashes, itching, and respiratory symptoms such as coughing and wheezing.
Immune Modulation:
Helminths have evolved mechanisms to modulate the host immune response to promote their survival within the body. This modulation can have both beneficial and detrimental effects on the host's immune system.
Chronic helminth infections have been associated with a reduced risk of autoimmune and inflammatory conditions such as allergies, asthma, and inflammatory bowel disease due to the dampening of the immune response.
However, excessive immune modulation by helminths can also impair the host's ability to mount an effective immune response against other infections and may contribute to chronic inflammation.
Organ Damage:
Severe or chronic helminth infections can lead to organ damage, especially if left untreated. For example, liver fluke infections (e.g., caused by Fasciola species) can cause liver fibrosis and bile duct obstruction, while schistosomiasis can lead to bladder or kidney damage.
Neurological Symptoms:
Certain helminth infections, such as neurocysticercosis (caused by the larval stage of the pork tapeworm, Taenia solium), can affect the central nervous system and cause neurological symptoms such as seizures, headaches, and cognitive impairment.
Transmission of Other Diseases:
Helminth infections can facilitate the transmission of other infectious diseases. For example, individuals infected with soil-transmitted helminths may have poor hygiene practices, increasing the risk of transmitting fecal-oral pathogens such as bacteria and viruses.
Bacteria Impacted by helminth infection (prescription)
We extend modifiers to include items that changes the parent and child taxa. I.e. for a species, that would be the genus that is belongs to and the strains in the species.
Impact of helminth infection (prescription) on Conditions from US National Library of Medicine
A higher number indicates impact on more bacteria associated with the condition and confidence on the impact.
We have X bacteria high and Y low reported. We find that the modifier reduces some and increases other of these two groups.
We just tally: X|reduces + Y|Increase = Positive β X|increases + Y|decrease = Negative.
Benefit Ratio: Numbers above 0 have increasing positive effect.
Numbers below 0 have increasing negative effect.
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