AI Engines For more Details: Perplexity Kagi Labs You
Vaginal Health: Lactobacillus crispatus plays a crucial role in maintaining vaginal health by producing lactic acid and other antimicrobial substances that create an acidic environment in the vagina. This acidic environment helps inhibit the growth of harmful bacteria and yeast, reducing the risk of vaginal infections such as bacterial vaginosis (BV), yeast infections, and urinary tract infections (UTIs).
Prevention of Bacterial Vaginosis (BV): Lactobacillus crispatus is particularly important for preventing bacterial vaginosis, a condition characterized by an overgrowth of harmful bacteria in the vagina. By producing lactic acid, L. crispatus helps maintain the acidic pH of the vagina, which inhibits the growth of BV-associated bacteria such as Gardnerella vaginalis.
Urinary Tract Health: Some research suggests that Lactobacillus crispatus may play a role in preventing urinary tract infections (UTIs) by colonizing the vagina and preventing the ascent of uropathogenic bacteria into the urinary tract. By maintaining a healthy vaginal microbiota, L. crispatus may help reduce the risk of recurrent UTIs, especially in women prone to these infections.
Sexual Health: Lactobacillus crispatus contributes to overall sexual health by promoting a balanced vaginal microbiota. Imbalances in vaginal microbiota composition can increase the risk of sexually transmitted infections (STIs) and other reproductive health issues. By maintaining a healthy vaginal environment, L. crispatus may help reduce the risk of STIs and support overall sexual well-being.
Pregnancy Health: A healthy vaginal microbiota, dominated by Lactobacillus crispatus, is important during pregnancy to reduce the risk of complications such as preterm birth and miscarriage. L. crispatus helps create an environment that is conducive to a healthy pregnancy by preventing infections and promoting a balanced immune response in the vaginal mucosa.
Gastrointestinal Health: Although Lactobacillus crispatus primarily colonizes the vaginal tract, some research suggests that it may have potential benefits for gastrointestinal health. Studies have shown that certain strains of L. crispatus can survive passage through the gastrointestinal tract and may exert probiotic effects, such as supporting immune function and promoting gut barrier integrity.
| Rank | Probiotic | Impact |
|---|---|---|
| species | Escherichia coli | Reduces |
| species | Lactobacillus acidophilus | Increases |
| species | Lactobacillus crispatus | Increases |
| species | Lactobacillus gasseri | Increases |
| species | Lactobacillus helveticus | Increases |
| species | Lactobacillus jensenii | Increases |
| species | Lactobacillus johnsonii | Increases |
| species | Lactobacillus kefiranofaciens | Increases |
We extend modifiers to include items that changes the parent and child taxa. I.e. for a species, that would be the genus that is belongs to and the strains in the species.
A higher number indicates impact on more bacteria associated with the condition and confidence on the impact.
We have X bacteria high and Y low reported. We find that the modifier reduces some and increases other of these two groups. We just tally: X|reduces + Y|Increase = Positive X|increases + Y|decrease = Negative.
Benefit Ratio:
Numbers above 0 have increasing positive effect.
Numbers below 0 have increasing negative effect.
| Condition | Positive Impact | Negative Impact | Benefit Ratio Impact |
|---|---|---|---|
| Acne | 1.3 | 1.3 | |
| ADHD | 1.7 | 0.6 | 1.83 |
| Allergic Rhinitis (Hay Fever) | 1.8 | 0.5 | 2.6 |
| Allergies | 2.9 | 1.7 | 0.71 |
| Allergy to milk products | 0.7 | 0.6 | 0.17 |
| Alopecia (Hair Loss) | 0.5 | 0.5 | |
| Alzheimer's disease | 2.6 | 2 | 0.3 |
| Amyotrophic lateral sclerosis (ALS) Motor Neuron | 1.1 | 1.1 | 0 |
| Ankylosing spondylitis | 3.4 | 0.9 | 2.78 |
| Anorexia Nervosa | 0.8 | 0.2 | 3 |
| Antiphospholipid syndrome (APS) | 1.6 | 1.6 | |
| Asthma | 1.5 | 0.6 | 1.5 |
| Atherosclerosis | 1.4 | 1.1 | 0.27 |
| Atrial fibrillation | 1.1 | 1.8 | -0.64 |
| Autism | 3 | 2.9 | 0.03 |
| Autoimmune Disease | 1.8 | 0.2 | 8 |
| Barrett esophagus cancer | 0.5 | 0.5 | |
| benign prostatic hyperplasia | 0.6 | 0.6 | |
| Biofilm | 2 | 2 | |
| Bipolar Disorder | 1.4 | 1.4 | |
| Brain Trauma | 0.6 | 0.3 | 1 |
| Breast Cancer | 0.5 | 0.5 | |
| Cancer (General) | 0.6 | 1 | -0.67 |
| Carcinoma | 1.8 | 1.8 | 0 |
| Celiac Disease | 2 | 1.8 | 0.11 |
| Cerebral Palsy | 0.2 | 0.2 | |
| Chronic Fatigue Syndrome | 2.2 | 1.1 | 1 |
| Chronic Kidney Disease | 1.8 | 1.8 | |
| Chronic Obstructive Pulmonary Disease (COPD) | 0.5 | 0.6 | -0.2 |
| Chronic Urticaria (Hives) | 1.3 | 1.3 | |
| Coagulation / Micro clot triggering bacteria | 1.6 | 1.6 | |
| Cognitive Function | 1.3 | 2.1 | -0.62 |
| Colorectal Cancer | 4.2 | 1.6 | 1.63 |
| Constipation | 2.3 | 2.3 | |
| Coronary artery disease | 2.2 | 2.2 | |
| COVID-19 | 3.9 | 1.6 | 1.44 |
| Crohn's Disease | 4.6 | 1.2 | 2.83 |
| cystic fibrosis | 1.1 | 1.1 | |
| d-lactic acidosis (one form of brain fog) | 1.6 | 1 | 0.6 |
| deep vein thrombosis | 1.6 | 1.6 | |
| Denture Wearers Oral Shifts | 0.6 | 0.6 | |
| Depression | 3.5 | 3.5 | 0 |
| Eczema | 1.2 | 0.2 | 5 |
| Endometriosis | 3.5 | 1.8 | 0.94 |
| Eosinophilic Esophagitis | 0.5 | 0.5 | |
| Epilepsy | 3.9 | 3.9 | |
| erectile dysfunction | 1.3 | 0.6 | 1.17 |
| Fibromyalgia | 1.9 | 0.8 | 1.37 |
| Functional constipation / chronic idiopathic constipation | 3.5 | 0.2 | 16.5 |
| gallstone disease (gsd) | 2.9 | 0.8 | 2.62 |
| Gastroesophageal reflux disease (Gerd) including Barrett's esophagus | 0.7 | 1.5 | -1.14 |
| Generalized anxiety disorder | 1.1 | 0.5 | 1.2 |
| giant cell arteritis | 0.3 | 0.2 | 0.5 |
| Gout | 1.4 | 1.1 | 0.27 |
| Graves' disease | 1.4 | 1.7 | -0.21 |
| Gulf War Syndrome | 0.2 | 0.2 | |
| Halitosis | 0.5 | 0.5 | |
| Hashimoto's thyroiditis | 1.9 | 1.9 | |
| Heart Failure | 2.4 | 0.6 | 3 |
| hemorrhagic stroke | 1.7 | 0.5 | 2.4 |
| High Histamine/low DAO | 1.2 | 0.6 | 1 |
| hypercholesterolemia (High Cholesterol) | 1 | 1 | |
| hyperglycemia | 2.1 | 2.1 | |
| Hyperlipidemia (High Blood Fats) | 1.3 | 0.6 | 1.17 |
| hypertension (High Blood Pressure | 2.1 | 1.5 | 0.4 |
| Hypothyroidism | 1.1 | 1.1 | |
| Hypoxia | 2.4 | 1 | 1.4 |
| IgA nephropathy (IgAN) | 1.1 | 0.8 | 0.38 |
| Inflammatory Bowel Disease | 4.1 | 1.9 | 1.16 |
| Insomnia | 0.9 | 0.7 | 0.29 |
| Intelligence | 0.7 | 0.7 | |
| Intracranial aneurysms | 1.1 | 1.1 | |
| Irritable Bowel Syndrome | 3.5 | 1.4 | 1.5 |
| ischemic stroke | 2 | 1.2 | 0.67 |
| Juvenile idiopathic arthritis | 0.5 | 0.5 | |
| Liver Cirrhosis | 3.2 | 1.9 | 0.68 |
| Long COVID | 1.8 | 2.1 | -0.17 |
| Low bone mineral density | 0.6 | -0.6 | |
| Lung Cancer | 0.6 | 0.6 | |
| Lymphoma | 0.6 | 0.6 | 0 |
| Mast Cell Issues / mastitis | 1.6 | 0.9 | 0.78 |
| ME/CFS with IBS | 0.8 | 0.8 | |
| ME/CFS without IBS | 0.2 | 0.2 | |
| Menopause | 1.6 | 1.6 | |
| Metabolic Syndrome | 4.6 | 2.4 | 0.92 |
| Mood Disorders | 4.1 | 3.5 | 0.17 |
| multiple chemical sensitivity [MCS] | 0.6 | -0.6 | |
| Multiple Sclerosis | 4 | 1.3 | 2.08 |
| Multiple system atrophy (MSA) | 0.6 | -0.6 | |
| myasthenia gravis | 0.6 | 0.2 | 2 |
| Neuropathy (all types) | 0.4 | 1.2 | -2 |
| neuropsychiatric disorders (PANDAS, PANS) | 1 | 1 | |
| Nonalcoholic Fatty Liver Disease (nafld) Nonalcoholic | 3.4 | 2.7 | 0.26 |
| NonCeliac Gluten Sensitivity | 0.6 | 0.6 | |
| Obesity | 5.1 | 2.8 | 0.82 |
| obsessive-compulsive disorder | 2.3 | 2.3 | |
| Osteoarthritis | 0.8 | 0.8 | |
| Osteoporosis | 1.8 | 1.7 | 0.06 |
| pancreatic cancer | 0.6 | 0.6 | |
| Parkinson's Disease | 4.8 | 1.8 | 1.67 |
| Peanut Allergy | 1.1 | -1.1 | |
| Polycystic ovary syndrome | 2.9 | 1.9 | 0.53 |
| Postural orthostatic tachycardia syndrome | 0.2 | 0.2 | |
| primary biliary cholangitis | 0 | 0.8 | 0 |
| Primary sclerosing cholangitis | 0.2 | 0.8 | -3 |
| Psoriasis | 1.9 | 1.2 | 0.58 |
| rheumatoid arthritis (RA),Spondyloarthritis (SpA) | 2.4 | 1.6 | 0.5 |
| Rosacea | 1.1 | 0.2 | 4.5 |
| Schizophrenia | 2.9 | 1.7 | 0.71 |
| scoliosis | 0.5 | 0.5 | |
| sensorineural hearing loss | 0.5 | 0.5 | |
| Sjögren syndrome | 1.2 | 0.8 | 0.5 |
| Sleep Apnea | 1.1 | -1.1 | |
| Slow gastric motility / Gastroparesis | 1.1 | 1.1 | |
| Small Intestinal Bacterial Overgrowth (SIBO) | 1.9 | 0.6 | 2.17 |
| Stress / posttraumatic stress disorder | 1.3 | 0.6 | 1.17 |
| Systemic Lupus Erythematosus | 1.6 | 1.1 | 0.45 |
| Tic Disorder | 0.6 | -0.6 | |
| Tourette syndrome | 0.6 | 0.6 | |
| Type 1 Diabetes | 2.5 | 0.8 | 2.13 |
| Type 2 Diabetes | 3.4 | 2.9 | 0.17 |
| Ulcerative colitis | 5.3 | 2.2 | 1.41 |
| Unhealthy Ageing | 0.7 | 1.2 | -0.71 |
| Vitiligo | 0.5 | -0.5 |
