AI Engines For more Details: Perplexity Kagi Labs You
Gastrointestinal Health: Lactobacillus salivarius has been extensively studied for its beneficial effects on gastrointestinal health. It may help maintain the balance of gut microbiota, support digestive function, and contribute to the integrity of the intestinal barrier. By producing antimicrobial substances and competing with harmful bacteria for nutrients and adhesion sites, Lactobacillus salivarius may help prevent or alleviate gastrointestinal disorders such as diarrhea, irritable bowel syndrome (IBS), and inflammatory bowel disease (IBD).
Immune System Support: Probiotics like Lactobacillus salivarius can modulate the immune system, enhancing both innate and adaptive immune responses. This bacterium may stimulate the production of antimicrobial peptides, promote phagocytosis, and regulate inflammatory cytokines. By interacting with immune cells in the gut-associated lymphoid tissue (GALT), Lactobacillus salivarius may help strengthen the body's natural defenses against infections and support overall immune function.
Oral Health: Lactobacillus salivarius is a predominant species in the oral microbiota and has been associated with oral health benefits. It may help inhibit the growth of pathogenic bacteria in the oral cavity, reduce plaque formation, and prevent dental caries. Incorporating Lactobacillus salivarius into oral care products or probiotic supplements may contribute to maintaining oral hygiene and preventing oral diseases such as periodontal disease and gingivitis.
Antimicrobial Activity: Lactobacillus salivarius produces antimicrobial compounds such as bacteriocins, hydrogen peroxide, and organic acids, which exhibit inhibitory effects against various pathogens including bacteria, fungi, and viruses. This antimicrobial activity may help protect against infections in the gastrointestinal tract and other mucosal surfaces.
Respiratory Health: Some research suggests that Lactobacillus salivarius may have potential benefits for respiratory health. It may help modulate immune responses in the respiratory tract and reduce the risk of respiratory infections such as the common cold, influenza, and bacterial pneumonia.
Skin Health: Emerging evidence indicates that Lactobacillus salivarius may have positive effects on skin health. It may help modulate the skin microbiota, reduce inflammation, and enhance skin barrier function. Lactobacillus salivarius-containing products may be used to improve conditions such as acne, eczema, and wound healing.
| Rank | Probiotic | Impact |
|---|---|---|
| species | Escherichia coli | Reduces |
| species | Lactobacillus acidophilus | Increases |
| species | Lactobacillus crispatus | Increases |
| species | Lactobacillus gasseri | Increases |
| species | Lactobacillus helveticus | Increases |
| species | Lactobacillus jensenii | Increases |
| species | Lactobacillus johnsonii | Increases |
| species | Lactobacillus kefiranofaciens | Increases |
We extend modifiers to include items that changes the parent and child taxa. I.e. for a species, that would be the genus that is belongs to and the strains in the species.
A higher number indicates impact on more bacteria associated with the condition and confidence on the impact.
We have X bacteria high and Y low reported. We find that the modifier reduces some and increases other of these two groups. We just tally: X|reduces + Y|Increase = Positive X|increases + Y|decrease = Negative.
Benefit Ratio:
Numbers above 0 have increasing positive effect.
Numbers below 0 have increasing negative effect.
| Condition | Positive Impact | Negative Impact | Benefit Ratio Impact |
|---|---|---|---|
| Abdominal Aortic Aneurysm | 0.4 | -0.4 | |
| Acne | 0.9 | 0.8 | 0.13 |
| ADHD | 2.5 | 3.3 | -0.32 |
| Age-Related Macular Degeneration and Glaucoma | 0.6 | 0.5 | 0.2 |
| Allergic Rhinitis (Hay Fever) | 2 | 2.1 | -0.05 |
| Allergies | 6.5 | 3.4 | 0.91 |
| Allergy to milk products | 2.4 | 2.3 | 0.04 |
| Alopecia (Hair Loss) | 1.6 | 1.6 | |
| Alzheimer's disease | 5.9 | 6.1 | -0.03 |
| Amyotrophic lateral sclerosis (ALS) Motor Neuron | 3.8 | 2.7 | 0.41 |
| Ankylosing spondylitis | 6.6 | 4.1 | 0.61 |
| Anorexia Nervosa | 2.2 | 2.8 | -0.27 |
| Antiphospholipid syndrome (APS) | 0.7 | 0.7 | |
| Asthma | 4.2 | 4.4 | -0.05 |
| Atherosclerosis | 1.4 | 1.7 | -0.21 |
| Atrial fibrillation | 4 | 4.1 | -0.02 |
| Autism | 7.8 | 9.2 | -0.18 |
| Autoimmune Disease | 1.6 | 0.6 | 1.67 |
| benign prostatic hyperplasia | 1.4 | 0.3 | 3.67 |
| Biofilm | 0.5 | 0.5 | |
| Bipolar Disorder | 1.6 | 2.5 | -0.56 |
| Brain Trauma | 3.6 | 0.3 | 11 |
| Breast Cancer | 0.9 | 0.9 | |
| Cancer (General) | 0.6 | 0.4 | 0.5 |
| Carcinoma | 3.2 | 2.7 | 0.19 |
| Celiac Disease | 4.4 | 3.9 | 0.13 |
| Cerebral Palsy | 0.8 | 1.8 | -1.25 |
| Chronic Fatigue Syndrome | 2.8 | 4.1 | -0.46 |
| Chronic Kidney Disease | 3.1 | 2.4 | 0.29 |
| Chronic Lyme | 1 | 0.3 | 2.33 |
| Chronic Obstructive Pulmonary Disease (COPD) | 2.3 | 2.8 | -0.22 |
| Chronic Urticaria (Hives) | 2 | 0.3 | 5.67 |
| Coagulation / Micro clot triggering bacteria | 1.5 | 2.3 | -0.53 |
| Cognitive Function | 3.3 | 3.3 | 0 |
| Colorectal Cancer | 6.3 | 5.2 | 0.21 |
| Constipation | 3.6 | 1.7 | 1.12 |
| Coronary artery disease | 4.4 | 2.7 | 0.63 |
| COVID-19 | 8.1 | 6.2 | 0.31 |
| Crohn's Disease | 7.3 | 6.7 | 0.09 |
| Cushing's Syndrome (hypercortisolism) | 0.5 | 0.5 | |
| cystic fibrosis | 2 | 0.7 | 1.86 |
| d-lactic acidosis (one form of brain fog) | 0.7 | 1 | -0.43 |
| deep vein thrombosis | 2.9 | 1.3 | 1.23 |
| Denture Wearers Oral Shifts | 0.9 | 0.9 | |
| Depression | 10 | 10 | 0 |
| Dermatomyositis | 0.4 | 0.3 | 0.33 |
| Eczema | 1.6 | 0.9 | 0.78 |
| Endometriosis | 4.5 | 2.9 | 0.55 |
| Eosinophilic Esophagitis | 0.6 | -0.6 | |
| Epilepsy | 4.9 | 3.2 | 0.53 |
| erectile dysfunction | 2.4 | 0.5 | 3.8 |
| Fibromyalgia | 2.6 | 1.7 | 0.53 |
| Functional constipation / chronic idiopathic constipation | 5.9 | 4 | 0.48 |
| gallstone disease (gsd) | 4.1 | 0.8 | 4.12 |
| Gastroesophageal reflux disease (Gerd) including Barrett's esophagus | 1.5 | 1.9 | -0.27 |
| Generalized anxiety disorder | 3.3 | 1.7 | 0.94 |
| giant cell arteritis | 0.3 | -0.3 | |
| Glioblastoma | 0.4 | 0.8 | -1 |
| Gout | 1.1 | 4.6 | -3.18 |
| Graves' disease | 3.1 | 5.3 | -0.71 |
| Gulf War Syndrome | 1 | 1.1 | -0.1 |
| Halitosis | 0.3 | 1.7 | -4.67 |
| Hashimoto's thyroiditis | 4 | 2.1 | 0.9 |
| Heart Failure | 3.3 | 3.7 | -0.12 |
| hemorrhagic stroke | 1.7 | 0.9 | 0.89 |
| Hidradenitis Suppurativa | 0.1 | 1.4 | -13 |
| High Histamine/low DAO | 1.9 | 0.9 | 1.11 |
| hypercholesterolemia (High Cholesterol) | 0.8 | 0.4 | 1 |
| hyperglycemia | 3.8 | 0.4 | 8.5 |
| Hyperlipidemia (High Blood Fats) | 2.5 | 0.5 | 4 |
| hypersomnia | 1.6 | -1.6 | |
| hypertension (High Blood Pressure | 5.9 | 4.7 | 0.26 |
| Hypothyroidism | 0.2 | 2.8 | -13 |
| Hypoxia | 2.7 | 1.1 | 1.45 |
| IgA nephropathy (IgAN) | 2.6 | 2.2 | 0.18 |
| Inflammatory Bowel Disease | 5.3 | 5.4 | -0.02 |
| Insomnia | 3.7 | 3.2 | 0.16 |
| Intelligence | 2.6 | 0.5 | 4.2 |
| Intracranial aneurysms | 1.3 | 1.4 | -0.08 |
| Irritable Bowel Syndrome | 7.4 | 5.4 | 0.37 |
| ischemic stroke | 2.9 | 5.1 | -0.76 |
| Juvenile idiopathic arthritis | 0.6 | -0.6 | |
| Liver Cirrhosis | 6.5 | 4.1 | 0.59 |
| Long COVID | 9 | 6 | 0.5 |
| Low bone mineral density | 1.1 | 1.2 | -0.09 |
| Lung Cancer | 0.9 | 1.5 | -0.67 |
| Lymphoma | 1.5 | 1.5 | |
| Mast Cell Issues / mastitis | 2.7 | 1.1 | 1.45 |
| ME/CFS with IBS | 0.5 | 0.6 | -0.2 |
| ME/CFS without IBS | 0.5 | 0.3 | 0.67 |
| membranous nephropathy | 0.6 | -0.6 | |
| Menopause | 0.7 | 0.6 | 0.17 |
| Metabolic Syndrome | 7 | 7 | 0 |
| Mood Disorders | 8.8 | 9.7 | -0.1 |
| multiple chemical sensitivity [MCS] | 1 | -1 | |
| Multiple Sclerosis | 3.5 | 3.4 | 0.03 |
| Multiple system atrophy (MSA) | 1 | -1 | |
| myasthenia gravis | 1.7 | 0.8 | 1.13 |
| neuropathic pain | 0.5 | 0.9 | -0.8 |
| Neuropathy (all types) | 1.8 | 1.9 | -0.06 |
| neuropsychiatric disorders (PANDAS, PANS) | 0.5 | 1.7 | -2.4 |
| Nonalcoholic Fatty Liver Disease (nafld) Nonalcoholic | 8.9 | 4.8 | 0.85 |
| NonCeliac Gluten Sensitivity | 1.5 | 0.5 | 2 |
| Obesity | 9.3 | 6.4 | 0.45 |
| obsessive-compulsive disorder | 3.4 | 3.6 | -0.06 |
| Osteoarthritis | 1.9 | 0.8 | 1.37 |
| Osteoporosis | 4.8 | 2.8 | 0.71 |
| pancreatic cancer | 0.5 | 0.5 | 0 |
| Parkinson's Disease | 6.4 | 8.3 | -0.3 |
| Peanut Allergy | 1.2 | 0.5 | 1.4 |
| Polycystic ovary syndrome | 6.6 | 5.5 | 0.2 |
| Postural orthostatic tachycardia syndrome | 0.8 | 0.3 | 1.67 |
| Premenstrual dysphoric disorder | 0.7 | 0.3 | 1.33 |
| primary biliary cholangitis | 0.8 | 1 | -0.25 |
| Primary sclerosing cholangitis | 3.2 | -3.2 | |
| Psoriasis | 2.7 | 1.7 | 0.59 |
| rheumatoid arthritis (RA),Spondyloarthritis (SpA) | 9 | 5.4 | 0.67 |
| Rosacea | 0.6 | 0.3 | 1 |
| Schizophrenia | 5.1 | 5.8 | -0.14 |
| scoliosis | 1.7 | 1.7 | |
| sensorineural hearing loss | 1.1 | -1.1 | |
| Sjögren syndrome | 2.8 | 2.7 | 0.04 |
| Sleep Apnea | 3.8 | 1.3 | 1.92 |
| Slow gastric motility / Gastroparesis | 1.5 | 0.8 | 0.88 |
| Small Intestinal Bacterial Overgrowth (SIBO) | 1.8 | 1.4 | 0.29 |
| Stress / posttraumatic stress disorder | 2.9 | 2.1 | 0.38 |
| Systemic Lupus Erythematosus | 5.7 | 4.6 | 0.24 |
| Tic Disorder | 1 | 0.7 | 0.43 |
| Tourette syndrome | 1.4 | 0.3 | 3.67 |
| Type 1 Diabetes | 4.4 | 3 | 0.47 |
| Type 2 Diabetes | 7.5 | 6.3 | 0.19 |
| Ulcerative colitis | 8.5 | 4.8 | 0.77 |
| Unhealthy Ageing | 2.8 | 1.9 | 0.47 |
| Vitiligo | 1.3 | 0.8 | 0.63 |
