AI Engines For more Details: Perplexity Kagi Labs You
Intestinal Amebiasis: Paromomycin sulfate is effective in the treatment of intestinal amebiasis, a parasitic infection caused by the protozoan parasite Entamoeba histolytica. It works by inhibiting protein synthesis in the parasite, leading to its death and clearance from the gastrointestinal tract.
Amoebic Liver Abscess: In addition to treating intestinal amebiasis, Paromomycin sulfate may also be used in combination with other medications for the treatment of amoebic liver abscess, a complication of intestinal amebiasis where the parasite spreads to the liver and forms abscesses.
Cryptosporidiosis: Paromomycin sulfate is used to treat cryptosporidiosis, a diarrheal illness caused by the protozoan parasite Cryptosporidium parvum. It can help reduce the severity and duration of diarrhea in immunocompetent individuals.
Bacterial Infections: Paromomycin sulfate exhibits antibacterial activity against certain Gram-negative bacteria. It may be used in the treatment of bacterial infections, particularly those involving the gastrointestinal tract.
Dosage and Administration: The dosage of Paromomycin sulfate varies depending on the type and severity of the infection, as well as the patient's age, weight, and renal function. It is typically administered orally in the form of tablets or capsules. For certain parasitic infections, Paromomycin sulfate may also be given as a rectal enema.
Mechanism of Action: Paromomycin sulfate belongs to the class of aminoglycoside antibiotics. It works by binding to the bacterial or parasitic ribosome, thereby inhibiting protein synthesis and ultimately leading to cell death. This mechanism of action is effective against both bacteria and parasites.
Adverse Effects: Common side effects of Paromomycin sulfate may include gastrointestinal disturbances such as nausea, vomiting, diarrhea, and abdominal pain. These side effects are usually mild and transient. Rare but serious adverse effects may include ototoxicity (damage to the ear) and nephrotoxicity (kidney damage), particularly with prolonged use or high doses.
Precautions: Paromomycin sulfate should be used with caution in patients with preexisting kidney or hearing impairment. It should not be used in individuals with known hypersensitivity to aminoglycoside antibiotics. Pregnant women and breastfeeding mothers should consult with a healthcare professional before using Paromomycin sulfate.
Drug Interactions: Paromomycin sulfate may interact with certain medications, particularly other antibiotics or nephrotoxic drugs, potentially increasing the risk of adverse effects. It is important to inform a healthcare professional about all medications being taken before starting treatment with Paromomycin sulfate.
We extend modifiers to include items that changes the parent and child taxa. I.e. for a species, that would be the genus that is belongs to and the strains in the species.
A higher number indicates impact on more bacteria associated with the condition and confidence on the impact.
We have X bacteria high and Y low reported. We find that the modifier reduces some and increases other of these two groups. We just tally: X|reduces + Y|Increase = Positive X|increases + Y|decrease = Negative.
Benefit Ratio:
Numbers above 0 have increasing positive effect.
Numbers below 0 have increasing negative effect.
