AI Engines For more Details: Perplexity Kagi Labs You
Alzheimer's Disease: Tacrine, as mentioned earlier, was initially used in the treatment of Alzheimer's disease to enhance cognitive function by increasing levels of acetylcholine in the brain. However, its efficacy was limited, and it is not commonly prescribed today.
Liver Toxicity: Tacrine has been associated with hepatotoxicity, which can lead to liver damage or failure. Regular monitoring of liver function tests is typically required for individuals taking Tacrine.
Gastrointestinal Disturbances: Tacrine use has been linked to gastrointestinal side effects such as nausea, vomiting, diarrhea, and abdominal discomfort.
Muscle Weakness: Some individuals taking Tacrine have reported muscle weakness or fatigue as a side effect.
Other Side Effects: Tacrine may also cause other side effects such as dizziness, headache, insomnia, and tremors.
| Rank | Probiotic | Impact |
|---|---|---|
| genus | Bifidobacterium | Reduces |
| species | Akkermansia muciniphila | Reduces |
| species | Bacteroides uniformis | Reduces |
| species | Bacteroides xylanisolvens | Reduces |
| species | Bifidobacterium adolescentis | Reduces |
| species | Bifidobacterium longum | Reduces |
| species | Escherichia coli | Reduces |
| species | Lacticaseibacillus paracasei | Reduces |
| species | Parabacteroides distasonis | Reduces |
| subspecies | Bifidobacterium longum subsp. infantis | Reduces |
| subspecies | Bifidobacterium longum subsp. longum | Reduces |
We extend modifiers to include items that changes the parent and child taxa. I.e. for a species, that would be the genus that is belongs to and the strains in the species.
A higher number indicates impact on more bacteria associated with the condition and confidence on the impact.
We have X bacteria high and Y low reported. We find that the modifier reduces some and increases other of these two groups. We just tally: X|reduces + Y|Increase = Positive X|increases + Y|decrease = Negative.
Benefit Ratio:
Numbers above 0 have increasing positive effect.
Numbers below 0 have increasing negative effect.
| Condition | Positive Impact | Negative Impact | Benefit Ratio Impact |
|---|---|---|---|
| Abdominal Aortic Aneurysm | 0.3 | 0.3 | |
| Acne | 0.6 | 0.5 | 0.2 |
| ADHD | 4.4 | 1.7 | 1.59 |
| Age-Related Macular Degeneration and Glaucoma | 1.1 | 0.4 | 1.75 |
| Allergic Rhinitis (Hay Fever) | 3.1 | 3.2 | -0.03 |
| Allergies | 6.9 | 3.8 | 0.82 |
| Allergy to milk products | 1.8 | 1.6 | 0.13 |
| Alopecia (Hair Loss) | 1.5 | 1.5 | |
| Alzheimer's disease | 6.2 | 4.9 | 0.27 |
| Amyotrophic lateral sclerosis (ALS) Motor Neuron | 4 | 1.6 | 1.5 |
| Ankylosing spondylitis | 4.5 | 0.9 | 4 |
| Anorexia Nervosa | 1.3 | 2.5 | -0.92 |
| Antiphospholipid syndrome (APS) | 1.3 | 1.3 | |
| Asthma | 5.8 | 2.8 | 1.07 |
| Atherosclerosis | 2.3 | 2.1 | 0.1 |
| Atrial fibrillation | 3 | 1.6 | 0.88 |
| Autism | 8.4 | 8.3 | 0.01 |
| Autoimmune Disease | 1.2 | 1 | 0.2 |
| Barrett esophagus cancer | 0.6 | 0.3 | 1 |
| benign prostatic hyperplasia | 0.6 | 0.3 | 1 |
| Biofilm | 2 | 2 | |
| Bipolar Disorder | 1.8 | 1.1 | 0.64 |
| Brain Trauma | 0.9 | 1.1 | -0.22 |
| Breast Cancer | 1.1 | 1.1 | |
| Cancer (General) | 0.9 | 3.2 | -2.56 |
| Carcinoma | 4.2 | 2.3 | 0.83 |
| Celiac Disease | 2.5 | 3.3 | -0.32 |
| Cerebral Palsy | 1.5 | 1 | 0.5 |
| Chronic Fatigue Syndrome | 3.8 | 4.7 | -0.24 |
| Chronic Kidney Disease | 4.1 | 1.5 | 1.73 |
| Chronic Lyme | 0.7 | 0.8 | -0.14 |
| Chronic Obstructive Pulmonary Disease (COPD) | 2.5 | 1.7 | 0.47 |
| Chronic Urticaria (Hives) | 2.1 | 0.8 | 1.63 |
| Coagulation / Micro clot triggering bacteria | 2 | 1 | 1 |
| Cognitive Function | 4.1 | 2.5 | 0.64 |
| Colorectal Cancer | 9 | 3.4 | 1.65 |
| Constipation | 2 | 1.6 | 0.25 |
| Coronary artery disease | 1.9 | 2 | -0.05 |
| COVID-19 | 9.3 | 8.3 | 0.12 |
| Crohn's Disease | 7.2 | 4.7 | 0.53 |
| Cushing's Syndrome (hypercortisolism) | 0.5 | -0.5 | |
| cystic fibrosis | 1.3 | 1.9 | -0.46 |
| d-lactic acidosis (one form of brain fog) | 0.7 | 0.7 | |
| deep vein thrombosis | 2.7 | 1.1 | 1.45 |
| Denture Wearers Oral Shifts | 1.4 | 1.4 | |
| Depression | 10.8 | 8.2 | 0.32 |
| Dermatomyositis | 0.3 | 0.3 | 0 |
| Eczema | 1.7 | 2.8 | -0.65 |
| Endometriosis | 3.3 | 2.1 | 0.57 |
| Eosinophilic Esophagitis | 0.3 | 0.6 | -1 |
| Epilepsy | 4.1 | 2.1 | 0.95 |
| erectile dysfunction | 1.4 | 0.3 | 3.67 |
| Fibromyalgia | 3 | 2 | 0.5 |
| Functional constipation / chronic idiopathic constipation | 5.2 | 3 | 0.73 |
| gallstone disease (gsd) | 3.4 | 1.3 | 1.62 |
| Gastroesophageal reflux disease (Gerd) including Barrett's esophagus | 1.4 | 1.3 | 0.08 |
| Generalized anxiety disorder | 2.7 | 2.3 | 0.17 |
| giant cell arteritis | 0.2 | -0.2 | |
| Glioblastoma | 0.3 | -0.3 | |
| Gout | 1.8 | 1 | 0.8 |
| Graves' disease | 1.6 | 2.7 | -0.69 |
| Gulf War Syndrome | 0.6 | 1.6 | -1.67 |
| Halitosis | 1.3 | 0.3 | 3.33 |
| Hashimoto's thyroiditis | 3.3 | 1.3 | 1.54 |
| Heart Failure | 3.8 | 1.6 | 1.37 |
| hemorrhagic stroke | 1.3 | 1.3 | |
| Hidradenitis Suppurativa | 1.2 | 0.3 | 3 |
| High Histamine/low DAO | 2.1 | 0.3 | 6 |
| hypercholesterolemia (High Cholesterol) | 1.2 | 0.4 | 2 |
| hyperglycemia | 2.9 | 1.7 | 0.71 |
| Hyperlipidemia (High Blood Fats) | 0.8 | 0.3 | 1.67 |
| hypersomnia | 0.4 | -0.4 | |
| hypertension (High Blood Pressure | 4.4 | 4.7 | -0.07 |
| Hypothyroidism | 1.1 | 0.7 | 0.57 |
| Hypoxia | 3.9 | 0.3 | 12 |
| IgA nephropathy (IgAN) | 1.6 | 3.3 | -1.06 |
| Inflammatory Bowel Disease | 8.7 | 7.6 | 0.14 |
| Insomnia | 2.6 | 2.4 | 0.08 |
| Intelligence | 1.6 | 0 | 0 |
| Intracranial aneurysms | 1.1 | 0.6 | 0.83 |
| Irritable Bowel Syndrome | 7.6 | 4.4 | 0.73 |
| ischemic stroke | 3.1 | 1.4 | 1.21 |
| Liver Cirrhosis | 7.3 | 4.6 | 0.59 |
| Long COVID | 4.9 | 6.6 | -0.35 |
| Low bone mineral density | 0.8 | -0.8 | |
| Lung Cancer | 1 | 1.1 | -0.1 |
| Lymphoma | 0.6 | 0.6 | |
| Mast Cell Issues / mastitis | 1 | 0.3 | 2.33 |
| ME/CFS with IBS | 0.5 | 1.7 | -2.4 |
| ME/CFS without IBS | 1 | 2.1 | -1.1 |
| membranous nephropathy | 0.3 | 0.3 | |
| Menopause | 2.6 | 0.7 | 2.71 |
| Metabolic Syndrome | 6.8 | 7 | -0.03 |
| Mood Disorders | 10.8 | 6.7 | 0.61 |
| multiple chemical sensitivity [MCS] | 1.1 | 0.1 | 10 |
| Multiple Sclerosis | 6.9 | 5.4 | 0.28 |
| Multiple system atrophy (MSA) | 1.7 | 0.4 | 3.25 |
| myasthenia gravis | 0.9 | 0.7 | 0.29 |
| neuropathic pain | 0.3 | 3.3 | -10 |
| Neuropathy (all types) | 0.9 | 3.1 | -2.44 |
| neuropsychiatric disorders (PANDAS, PANS) | 1.3 | 1.3 | |
| Nonalcoholic Fatty Liver Disease (nafld) Nonalcoholic | 5.2 | 4.2 | 0.24 |
| NonCeliac Gluten Sensitivity | 1.6 | 0.6 | 1.67 |
| Obesity | 10.1 | 8.1 | 0.25 |
| obsessive-compulsive disorder | 5.7 | 2.5 | 1.28 |
| Osteoarthritis | 1.8 | 1 | 0.8 |
| Osteoporosis | 2.5 | 1.9 | 0.32 |
| pancreatic cancer | 1.9 | 0.6 | 2.17 |
| Parkinson's Disease | 8.9 | 5.3 | 0.68 |
| Polycystic ovary syndrome | 5.3 | 2.2 | 1.41 |
| Postural orthostatic tachycardia syndrome | 0.2 | 0.3 | -0.5 |
| Premenstrual dysphoric disorder | 0.7 | 0.4 | 0.75 |
| primary biliary cholangitis | 1.2 | 1.3 | -0.08 |
| Primary sclerosing cholangitis | 3 | 2 | 0.5 |
| Psoriasis | 3.5 | 2.2 | 0.59 |
| rheumatoid arthritis (RA),Spondyloarthritis (SpA) | 5.9 | 3.6 | 0.64 |
| Rosacea | 0.5 | 1 | -1 |
| Schizophrenia | 6.9 | 2.6 | 1.65 |
| scoliosis | 0.7 | 0.3 | 1.33 |
| Sjögren syndrome | 2.7 | 2.5 | 0.08 |
| Sleep Apnea | 1.6 | 1.3 | 0.23 |
| Slow gastric motility / Gastroparesis | 1.3 | 0.3 | 3.33 |
| Small Intestinal Bacterial Overgrowth (SIBO) | 2 | 0.5 | 3 |
| Stress / posttraumatic stress disorder | 3.5 | 2.4 | 0.46 |
| Systemic Lupus Erythematosus | 3.5 | 2 | 0.75 |
| Tic Disorder | 0.8 | 2.3 | -1.87 |
| Tourette syndrome | 1 | 0.3 | 2.33 |
| Type 1 Diabetes | 4.5 | 4.1 | 0.1 |
| Type 2 Diabetes | 7.2 | 7.3 | -0.01 |
| Ulcerative colitis | 6.2 | 6.1 | 0.02 |
| Unhealthy Ageing | 3.7 | 1.7 | 1.18 |
| Vitiligo | 2 | 1.1 | 0.82 |
