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Tuberculosis (TB): Rifampicin is one of the first-line drugs used in the treatment of tuberculosis (TB), both drug-sensitive and drug-resistant strains. It is often used in combination with other antibiotics such as isoniazid, pyrazinamide, and ethambutol.
Mycobacterial Infections: Apart from TB, rifampicin may also be used to treat infections caused by other mycobacteria, including atypical mycobacterial infections such as Mycobacterium avium complex (MAC) infections.
Meningococcal Carriage: Rifampicin is used prophylactically to eradicate meningococcal carriage in individuals who have been in close contact with patients diagnosed with meningococcal disease.
Leprosy: Rifampicin is sometimes used in the treatment of leprosy (Hansen's disease) as part of multidrug therapy regimens recommended by the World Health Organization (WHO).
Brucellosis: Rifampicin may be used as part of combination therapy for the treatment of brucellosis, a bacterial infection caused by various species of Brucella.
Endocarditis: Rifampicin may be used in combination with other antibiotics for the treatment of infective endocarditis, particularly when caused by staphylococci or other susceptible bacteria.
Staphylococcal Infections: Rifampicin may be used in combination with other antibiotics for the treatment of staphylococcal infections, including infections caused by methicillin-resistant Staphylococcus aureus (MRSA).
Prosthetic Joint Infections: Rifampicin is sometimes used as part of combination therapy for the treatment of prosthetic joint infections, particularly those caused by staphylococci or other biofilm-forming bacteria.
Mycobacterium kansasii Infections: Rifampicin may be effective in the treatment of infections caused by Mycobacterium kansasii, a bacterium that can cause lung disease resembling tuberculosis.
Side Effects: Common side effects of rifampicin include gastrointestinal disturbances such as nausea, vomiting, diarrhea, and abdominal pain. It may also cause changes in urine color (orange-red), rash, fever, headache, and joint pain. Rifampicin may interact with other medications, including antiretroviral drugs used in the treatment of HIV/AIDS.
Drug Interactions: Rifampicin is a potent inducer of drug-metabolizing enzymes in the liver, particularly cytochrome P450 enzymes. Therefore, it can interact with many medications, including antiretroviral drugs (such as protease inhibitors and non-nucleoside reverse transcriptase inhibitors), antifungal agents, immunosuppressants, and oral contraceptives. Dose adjustments or careful monitoring may be necessary when rifampicin is used concomitantly with other medications.
Pregnancy and Lactation: The safety of rifampicin during pregnancy and lactation has not been well established. It should be used during pregnancy only if the potential benefits outweigh the potential risks. Breastfeeding should be avoided during rifampicin therapy.
(3-fd, 4-d plus, 4d, abrifam, afracin, akt-2, akt-3, akt-4, akt-fd, akurit, akurit kid, akurit-3, akurit-4, akurit-z, akurit-z kid, an si nuo kang, aptecin, arficin, benemicin, bifix, boie rifampicin, chang wei rui da xin, corifam, dai fei lin, de ji jin fei ke, duomax, econofix, eremfat, fei an, fei lu de, fei ning, fei su, fei ting, firifam, fixcom 3, fixcom 4, forecox-trac, fuhe, hr pedia kit, hrz pedia kit, hu fei te, ipcacin, iso-eremfat, isonarif, isoniazid rifampin-south ocean pharm, isorifa, kalrifam, ke lao er kang, kidz kit 2, kidz kit 3, lanarif, ls-rif, manorifcin, merimac, mycocox, mycocox-4, mycocox-e, mycocox-z, myrin, myrin-p forte, natricin, oboliz, pharex rifampicin, pi jin, pi lv, quadmax, quadtab, r-cinex, r-cinex kid, ricin, rif, rifacox-h, rifactine, rifadex, rifadin-inh, rifadine, rifadine 2%, rifafour, rifagen, rifaldin, rifalep, rifam, rifam plus, rifamate, rifamazid, rifamed, rifamor, rifamox, rifampicin - changzheng-xinkai pharm, rifampicin - sine, rifampicin adwic, rifampicin and isoniazid antibiotice, rifampicin central, rifampicin fulton, rifampicin indo farma, rifampicin labatec, rifampicin li ta, rifampicin root, rifampicin sandoz, rifampicin yuan chou, rifampicin yung shin, rifampicin-xinhua pharm, rifampicina, rifampicina + isoniacida kronos, rifampicinΓ£ arena, rifampicina colmed, rifampicina fabra, rifampicina kilab, rifampicina kronos, rifampicina magma, rifampicina mk, rifampicina richet, rifampicine labatec, rifampicine sandoz, rifampicyna polfa, rifampicyna tzf, rifampin pfizer, rifamtibi, rifanid, rifaren, rifasynt, rifater, rifazid, rifcap, rifinah, rifocin, rifoldin, rifoldin mit inh, rifzin, rimactan, rimactane, rimactazid, rimactazid + e, rimactazid + z, rimactazid paed, rimacure ped, rimaped, rimapen, rimcure, rimcure 3fdc, rimcure paed, rimmax 2f dc, rimpacin, rimpazid, rimpin, rimstar, rimstar 4fdc, rimstar-4, rimthree fdc, riozid, ripolin, risoped, risoped forte, ritemed rifampicin, rui fu an kang, scc-2, scc-3, scc-4, shu lan xin, sinerdol, sinerdol iso, tb rif, ter-3, ter-4, ti bi, tibikit, tibirim-inh, tibirim-inh forte, tisobrif, trac-3, trac-4, tres, tubocin, wei bao, wei fei, wei fu xin, yi bi fu, yi nuo ni kang, yi ti bi, zucox, zucox plus, zucox-2, zucox-3)
Rank | Probiotic | Impact |
---|---|---|
genus | Bifidobacterium | Reduces |
genus | Pediococcus | Reduces |
species | Akkermansia muciniphila | Reduces |
species | Bacteroides uniformis | Reduces |
species | Bifidobacterium adolescentis | Reduces |
species | Bifidobacterium animalis | Reduces |
species | Bifidobacterium bifidum | Reduces |
species | Bifidobacterium breve | Reduces |
species | Bifidobacterium catenulatum | Reduces |
species | Bifidobacterium longum | Reduces |
We extend modifiers to include items that changes the parent and child taxa. I.e. for a species, that would be the genus that is belongs to and the strains in the species.
Taxonomy | Rank | Effect | Citations | Notation |
---|---|---|---|---|
[Lactobacillus] rogosae | species | Decreases | πΆ Source Study | |
[Lactobacillus] rogosae | species | Decreases | πΆ Source Study | |
[Ruminococcus] torques | species | Decreases | π Source Study | |
Acetilactobacillus | genus | Decreases | πΆ Source Study | |
Acetilactobacillus jinshanensis | species | Decreases | πΆ Source Study | |
Acetilactobacillus jinshanensis | species | Decreases | πΆ Source Study | |
Aeriscardovia | genus | Decreases | πΆ Source Study | |
Agathobacter | genus | Decreases | πͺ Source Study | |
Agathobacter rectalis | species | Decreases | π Source Study | |
Agrilactobacillus | genus | Decreases | πΆ Source Study | |
Agrilactobacillus composti | species | Decreases | πΆ Source Study | |
Agrilactobacillus composti | species | Decreases | πΆ Source Study | |
Akkermansia | genus | Decreases | π Source Study | |
Akkermansia glycaniphila | species | Decreases | πΆ Source Study | |
Akkermansia massiliensis | species | Decreases | πΆ Source Study |
A higher number indicates impact on more bacteria associated with the condition and confidence on the impact.
We have X bacteria high and Y low reported. We find that the modifier reduces some and increases other of these two groups. We just tally: X|reduces + Y|Increase = Positive β X|increases + Y|decrease = Negative.
Benefit Ratio:
Numbers above 0 have increasing positive effect.
Numbers below 0 have increasing negative effect.
Condition | Positive Impact | Negative Impact | Benefit Ratio Impact |
---|---|---|---|
Abdominal Aortic Aneurysm | 0.9 | 0.9 | |
Acne | 1.1 | 1.9 | -0.73 |
Addison's Disease (hypocortisolism) | 0.5 | 0.5 | |
ADHD | 6.3 | 1.1 | 4.73 |
Age-Related Macular Degeneration and Glaucoma | 1.1 | 0.4 | 1.75 |
Allergic Rhinitis (Hay Fever) | 4.5 | 4.1 | 0.1 |
Allergies | 10.7 | 6.7 | 0.6 |
Allergy to milk products | 2.9 | 2 | 0.45 |
Alopecia (Hair Loss) | 1.6 | 1.6 | |
Alzheimer's disease | 8.4 | 9.9 | -0.18 |
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