🍽️ hexachlorophene

Antibacterial and Antifungal Properties:

• Hexachlorophene is effective against a wide range of bacteria and fungi. It works by disrupting the cell membrane of microorganisms, leading to their destruction.

Medical Uses:

• Historically, hexachlorophene has been used in topical medications and cleansers for various purposes, including:
  • Treatment of acne vulgaris (common acne).
  • Control of superficial skin infections.
  • Surgical scrubbing and handwashing in healthcare settings.
  • Prevention of body odor.
• It has also been used in some antiseptic soaps and cleansers for general hygiene.

Safety Concerns:

• Despite its efficacy as an antibacterial agent, hexachlorophene has been associated with significant safety concerns, particularly in infants and children.
• Prolonged or excessive exposure to hexachlorophene can lead to:
  • Neurotoxicity: Hexachlorophene can be absorbed through the skin and mucous membranes, leading to neurological damage. In infants, it has been linked to brain damage and developmental delays, a condition known as hexachlorophene toxicity or "hex disease."
  • Skin irritation: Topical use of hexachlorophene can cause skin irritation, dermatitis, or allergic reactions in some individuals.
  • Systemic toxicity: Ingestion or absorption of large amounts of hexachlorophene can lead to systemic toxicity, affecting various organs and systems in the body.

Regulatory Actions:

• Due to the recognized risks of hexachlorophene toxicity, regulatory agencies have restricted or banned its use in many products intended for personal care and hygiene.
• In the United States, the Food and Drug Administration (FDA) banned the use of hexachlorophene in over-the-counter healthcare antiseptic products intended for topical use in 1973.
• The use of hexachlorophene in prescription medications and other products is strictly regulated, and its use is limited to specific medical indications under the supervision of healthcare professionals.

Alternatives:

• Safer and more effective alternatives to hexachlorophene are available for the treatment of acne and other skin conditions. These alternatives include benzoyl peroxide, salicylic acid, antibiotics, and retinoids.
• Non-toxic alternatives for general hygiene and handwashing include soap and water, alcohol-based hand sanitizers, and other FDA-approved antiseptic agents.