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Lowering Blood Pressure: Felodipine belongs to a class of medications called calcium channel blockers. It works by relaxing the blood vessels, allowing blood to flow more easily and lowering blood pressure. By reducing blood pressure, felodipine helps decrease the risk of heart attacks, strokes, and other cardiovascular events associated with hypertension.
Treatment of Angina Pectoris: Felodipine is also used to treat chronic stable angina (chest pain) due to coronary artery disease. By dilating the coronary arteries and improving blood flow to the heart muscle, felodipine helps relieve chest pain and reduce the frequency and severity of angina attacks.
Prevention of Vasospasm: Felodipine may be used to prevent vasospasm, a condition characterized by sudden, temporary narrowing of the blood vessels. It can help prevent vasospasm-related complications in conditions such as Prinzmetal's angina and Raynaud's phenomenon.
Reduction of Cardiac Workload: By reducing arterial pressure and afterload (the force against which the heart pumps blood), felodipine helps decrease the workload on the heart, improving cardiac efficiency and reducing oxygen demand. This can be beneficial for individuals with heart failure or other cardiac conditions.
Management of Hypertension: Felodipine is often prescribed as a first-line treatment for hypertension, either alone or in combination with other antihypertensive medications. It helps control blood pressure levels and reduces the risk of complications associated with hypertension, such as stroke, heart attack, kidney disease, and vascular damage.
Long-acting Formulation: Felodipine is available in extended-release formulations, which provide sustained blood pressure control over a 24-hour period with once-daily dosing. This allows for convenient and effective management of hypertension and angina.
Side Effects: Common side effects of felodipine may include headache, dizziness, flushing, swelling of the ankles or feet (peripheral edema), and flushing. These side effects are usually mild and transient. Less common but more serious side effects may include rapid heartbeat, chest pain, shortness of breath, fainting, and signs of liver problems.
Drug Interactions: Felodipine may interact with certain medications, including other antihypertensive drugs, beta-blockers, antiarrhythmics, and drugs metabolized by the cytochrome P450 enzyme system. It is important to inform the healthcare provider about all medications, supplements, and health conditions before starting felodipine therapy to prevent potential interactions and adverse effects.
Precautions: Felodipine should be used with caution in individuals with liver dysfunction, congestive heart failure, aortic stenosis, and severe hypotension. It is not recommended during pregnancy or breastfeeding unless the potential benefits outweigh the risks. Dosage adjustments may be necessary in elderly patients and those with impaired renal function.
Regular Monitoring: Patients taking felodipine should undergo regular blood pressure monitoring and medical follow-up to assess treatment efficacy and safety. Adjustments to the dosage or medication regimen may be made based on individual response and clinical status.
We extend modifiers to include items that changes the parent and child taxa. I.e. for a species, that would be the genus that is belongs to and the strains in the species.
A higher number indicates impact on more bacteria associated with the condition and confidence on the impact.
We have X bacteria high and Y low reported. We find that the modifier reduces some and increases other of these two groups. We just tally: X|reduces + Y|Increase = Positive β X|increases + Y|decrease = Negative.
Benefit Ratio:
Numbers above 0 have increasing positive effect.
Numbers below 0 have increasing negative effect.