Cholesterol Reduction: Simvastatin belongs to a class of medications called statins, which work by inhibiting an enzyme involved in cholesterol synthesis in the liver. By reducing the production of cholesterol, simvastatin helps lower levels of LDL cholesterol (often referred to as "bad" cholesterol) and triglycerides while increasing levels of HDL cholesterol (often referred to as "good" cholesterol).
Cardiovascular Risk Reduction: Lowering LDL cholesterol levels with simvastatin has been shown to reduce the risk of cardiovascular events such as heart attacks, strokes, and coronary artery disease. It can also slow the progression of existing cardiovascular disease and reduce the need for interventions such as angioplasty or bypass surgery.
Prevention of Atherosclerosis: Atherosclerosis is a condition characterized by the buildup of plaque in the arteries, which can lead to narrowed or blocked arteries and increase the risk of cardiovascular events. Simvastatin helps prevent atherosclerosis by lowering LDL cholesterol levels and reducing inflammation in the blood vessels.
Secondary Prevention: Simvastatin is often prescribed to individuals who have already experienced a cardiovascular event, such as a heart attack or stroke, to reduce the risk of recurrent events and improve long-term outcomes.
Primary Prevention: In addition to secondary prevention, simvastatin may also be prescribed to individuals who have multiple risk factors for cardiovascular disease but have not yet experienced a cardiovascular event. This includes individuals with high cholesterol levels, hypertension, diabetes, or a family history of premature cardiovascular disease.
Combination Therapy: Simvastatin may be prescribed alone or in combination with other lipid-lowering medications, such as ezetimibe, to achieve optimal cholesterol control and further reduce the risk of cardiovascular events.
Dose Adjustment: The dose of simvastatin is typically individualized based on the patient's cholesterol levels, cardiovascular risk factors, and response to treatment. It is important for patients to adhere to the prescribed dosage and follow-up with their healthcare provider for regular monitoring of cholesterol levels and liver function.
Adverse Effects: While simvastatin is generally well-tolerated, it can cause side effects in some individuals. Common side effects may include muscle pain or weakness, gastrointestinal symptoms (such as nausea, diarrhea, or constipation), headache, and elevated liver enzymes. Rare but serious side effects may include muscle breakdown (rhabdomyolysis), liver damage, and an increased risk of diabetes.
Contraindications: Simvastatin is contraindicated in individuals with active liver disease or unexplained persistent elevations in liver enzymes, as well as in pregnant or breastfeeding women. It may also interact with certain medications, including some antibiotics, antifungal agents, and immunosuppressants, so it is important for patients to inform their healthcare provider about all medications they are taking.
Lifestyle Modifications: In addition to medication therapy, lifestyle modifications such as a heart-healthy diet, regular exercise, weight management, smoking cessation, and limiting alcohol intake are important components of cardiovascular risk reduction and may enhance the effectiveness of simvastatin therapy.
Impacted of simvastatin,(prescription) On Probiotics
Rank
Probiotic
Impact
genus
Bifidobacterium
Reduces
species
Akkermansia muciniphila
Reduces
species
Bacillus subtilis
Reduces
species
Bacteroides uniformis
Reduces
species
Bifidobacterium adolescentis
Reduces
species
Bifidobacterium longum
Reduces
species
Escherichia coli
Reduces
species
Lacticaseibacillus paracasei
Reduces
species
Parabacteroides distasonis
Reduces
subspecies
Bacillus subtilis subsp. natto
Reduces
subspecies
Bifidobacterium longum subsp. infantis
Reduces
subspecies
Bifidobacterium longum subsp. longum
Reduces
Bacteria Impacted by simvastatin,(prescription)
We extend modifiers to include items that changes the parent and child taxa. I.e. for a species, that would be the genus that is belongs to and the strains in the species.
Impact of simvastatin,(prescription) on Conditions from US National Library of Medicine
A higher number indicates impact on more bacteria associated with the condition and confidence on the impact.
We have X bacteria high and Y low reported. We find that the modifier reduces some and increases other of these two groups.
We just tally: X|reduces + Y|Increase = Positive X|increases + Y|decrease = Negative.
Benefit Ratio: Numbers above 0 have increasing positive effect.
Numbers below 0 have increasing negative effect.
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