AI Engines For more Details: Perplexity Kagi Labs You
Hypertension: Nicardipine hydrochloride effectively lowers blood pressure by blocking calcium channels in blood vessels, leading to vasodilation (widening of blood vessels) and reduced peripheral resistance. By decreasing systemic vascular resistance, nicardipine helps improve blood flow and reduce blood pressure levels.
Angina Pectoris: Nicardipine may be used to manage chronic stable angina (angina pectoris), a condition characterized by chest pain or discomfort due to reduced blood flow to the heart muscle. By dilating coronary arteries and increasing myocardial oxygen delivery, nicardipine helps relieve anginal symptoms and improve exercise tolerance.
Hypertensive Crisis: Nicardipine is often administered intravenously in hospital settings to treat hypertensive emergencies or severe hypertension that requires rapid blood pressure reduction to prevent organ damage. Its rapid onset of action and ability to lower blood pressure safely make it a preferred option for hypertensive crises.
Coronary Artery Disease: Nicardipine may benefit individuals with coronary artery disease (CAD) by improving coronary blood flow and reducing myocardial ischemia (insufficient blood supply to the heart muscle). It can help alleviate symptoms of CAD, such as chest pain, and may also have cardioprotective effects.
Subarachnoid Hemorrhage: Intravenous nicardipine is sometimes used to manage hypertension associated with subarachnoid hemorrhage, a type of stroke caused by bleeding into the space surrounding the brain. By lowering blood pressure, nicardipine helps prevent rebleeding and reduces the risk of neurological complications.
Raynaud's Phenomenon: Nicardipine's vasodilatory effects may benefit individuals with Raynaud's phenomenon, a condition characterized by episodic vasospasm of peripheral arteries, leading to reduced blood flow to the extremities. By promoting peripheral vasodilation, nicardipine may help alleviate symptoms such as cold fingers and toes.
Vasospastic Angina (Prinzmetal's Angina): Nicardipine is effective in managing vasospastic angina, also known as Prinzmetal's angina or variant angina, which occurs due to coronary artery vasospasm. By relaxing coronary arteries and preventing vasospasm, nicardipine helps relieve anginal symptoms and reduce the frequency of angina attacks.
| Rank | Probiotic | Impact |
|---|---|---|
| genus | Bifidobacterium | Reduces |
| species | Akkermansia muciniphila | Reduces |
| species | Bacteroides uniformis | Reduces |
| species | Bifidobacterium adolescentis | Reduces |
| species | Bifidobacterium longum | Reduces |
| species | Escherichia coli | Reduces |
| species | Parabacteroides distasonis | Reduces |
| subspecies | Bifidobacterium longum subsp. infantis | Reduces |
| subspecies | Bifidobacterium longum subsp. longum | Reduces |
We extend modifiers to include items that changes the parent and child taxa. I.e. for a species, that would be the genus that is belongs to and the strains in the species.
A higher number indicates impact on more bacteria associated with the condition and confidence on the impact.
We have X bacteria high and Y low reported. We find that the modifier reduces some and increases other of these two groups. We just tally: X|reduces + Y|Increase = Positive X|increases + Y|decrease = Negative.
Benefit Ratio:
Numbers above 0 have increasing positive effect.
Numbers below 0 have increasing negative effect.
| Condition | Positive Impact | Negative Impact | Benefit Ratio Impact |
|---|---|---|---|
| Abdominal Aortic Aneurysm | 0.6 | 0.6 | |
| Acne | 0.3 | -0.3 | |
| ADHD | 4.3 | 0.6 | 6.17 |
| Age-Related Macular Degeneration and Glaucoma | 1.1 | 0.4 | 1.75 |
| Allergic Rhinitis (Hay Fever) | 3.4 | 1.8 | 0.89 |
| Allergies | 4.6 | 2.2 | 1.09 |
| Allergy to milk products | 1.3 | 1.6 | -0.23 |
| Alopecia (Hair Loss) | 1.6 | 1.6 | |
| Alzheimer's disease | 5.7 | 7 | -0.23 |
| Amyotrophic lateral sclerosis (ALS) Motor Neuron | 2.8 | 0.2 | 13 |
| Ankylosing spondylitis | 4.1 | 1.2 | 2.42 |
| Anorexia Nervosa | 1.3 | 2.6 | -1 |
| Antiphospholipid syndrome (APS) | 1.6 | 1.6 | |
| Asthma | 4.8 | 2.2 | 1.18 |
| Atherosclerosis | 1.9 | 2 | -0.05 |
| Atrial fibrillation | 3.5 | 2.8 | 0.25 |
| Autism | 9.1 | 8.5 | 0.07 |
| Autoimmune Disease | 1.2 | 1 | 0.2 |
| Barrett esophagus cancer | 0.6 | 0.3 | 1 |
| benign prostatic hyperplasia | 0.6 | 0.3 | 1 |
| Biofilm | 2.1 | 2.1 | |
| Bipolar Disorder | 1.8 | 1.4 | 0.29 |
| Brain Trauma | 0.9 | 1.1 | -0.22 |
| Breast Cancer | 0.5 | 0.5 | |
| Cancer (General) | 0.9 | 1.8 | -1 |
| Carcinoma | 4.1 | 2.3 | 0.78 |
| Celiac Disease | 3.1 | 2.7 | 0.15 |
| Cerebral Palsy | 1.4 | 1 | 0.4 |
| Chronic Fatigue Syndrome | 4.1 | 5.5 | -0.34 |
| Chronic Kidney Disease | 5.1 | 2.4 | 1.13 |
| Chronic Lyme | 0.6 | 0.8 | -0.33 |
| Chronic Obstructive Pulmonary Disease (COPD) | 2.1 | 1.7 | 0.24 |
| Chronic Urticaria (Hives) | 1.5 | 1.3 | 0.15 |
| Coagulation / Micro clot triggering bacteria | 1.4 | 1 | 0.4 |
| Cognitive Function | 2.2 | 1.6 | 0.38 |
| Colorectal Cancer | 7.1 | 2.3 | 2.09 |
| Constipation | 1.5 | 0.7 | 1.14 |
| Coronary artery disease | 2.2 | 3 | -0.36 |
| COVID-19 | 8.4 | 11 | -0.31 |
| Crohn's Disease | 8.6 | 4.8 | 0.79 |
| Cushing's Syndrome (hypercortisolism) | 0.9 | -0.9 | |
| cystic fibrosis | 0.7 | 1.6 | -1.29 |
| d-lactic acidosis (one form of brain fog) | 0.1 | 0.1 | |
| deep vein thrombosis | 2 | 1.1 | 0.82 |
| Denture Wearers Oral Shifts | 1.2 | 1.2 | |
| Depression | 9.8 | 8.5 | 0.15 |
| Dermatomyositis | 0.3 | 0.3 | 0 |
| Eczema | 2.3 | 2.1 | 0.1 |
| Endometriosis | 3 | 1.5 | 1 |
| Eosinophilic Esophagitis | 0.3 | 0.6 | -1 |
| Epilepsy | 3.1 | 1.9 | 0.63 |
| erectile dysfunction | 1.4 | 0.3 | 3.67 |
| Fibromyalgia | 3.7 | 2.2 | 0.68 |
| Functional constipation / chronic idiopathic constipation | 5.6 | 4.6 | 0.22 |
| gallstone disease (gsd) | 3.5 | 1.2 | 1.92 |
| Gastroesophageal reflux disease (Gerd) including Barrett's esophagus | 2.2 | 0.4 | 4.5 |
| Generalized anxiety disorder | 2.9 | 1.8 | 0.61 |
| giant cell arteritis | 0.2 | -0.2 | |
| Glioblastoma | 0.3 | -0.3 | |
| Gout | 1.2 | 0.6 | 1 |
| Graves' disease | 1.6 | 3 | -0.88 |
| Gulf War Syndrome | 0.9 | 1.7 | -0.89 |
| Halitosis | 1.5 | 0.3 | 4 |
| Hashimoto's thyroiditis | 3.7 | 1.2 | 2.08 |
| Heart Failure | 3.8 | 1.6 | 1.37 |
| hemorrhagic stroke | 1.3 | 1.3 | |
| Hidradenitis Suppurativa | 0.9 | 0.3 | 2 |
| High Histamine/low DAO | 1 | 0.3 | 2.33 |
| hypercholesterolemia (High Cholesterol) | 0.6 | 0.1 | 5 |
| hyperglycemia | 1.9 | 1.3 | 0.46 |
| Hyperlipidemia (High Blood Fats) | 0.6 | 0.3 | 1 |
| hypersomnia | 0.4 | -0.4 | |
| hypertension (High Blood Pressure | 4.3 | 4.7 | -0.09 |
| Hypothyroidism | 0.1 | 1 | -9 |
| Hypoxia | 2.7 | 0.3 | 8 |
| IgA nephropathy (IgAN) | 1.6 | 4.4 | -1.75 |
| Inflammatory Bowel Disease | 8.6 | 7.4 | 0.16 |
| Insomnia | 2.3 | 2 | 0.15 |
| Intelligence | 1.5 | 0.6 | 1.5 |
| Intracranial aneurysms | 1.1 | 0.6 | 0.83 |
| Irritable Bowel Syndrome | 7.1 | 4.9 | 0.45 |
| ischemic stroke | 2.2 | 1.7 | 0.29 |
| Liver Cirrhosis | 7 | 3.9 | 0.79 |
| Long COVID | 7.1 | 5.3 | 0.34 |
| Low bone mineral density | 0.8 | -0.8 | |
| Lung Cancer | 1.2 | 0.8 | 0.5 |
| Lymphoma | 0.6 | 0.6 | |
| Mast Cell Issues / mastitis | 1.3 | 0.6 | 1.17 |
| ME/CFS with IBS | 0.5 | 1 | -1 |
| ME/CFS without IBS | 1.5 | 1.9 | -0.27 |
| membranous nephropathy | 0.3 | 0.3 | |
| Menopause | 1.6 | 0.6 | 1.67 |
| Metabolic Syndrome | 6.9 | 7.5 | -0.09 |
| Mood Disorders | 8.9 | 6.4 | 0.39 |
| multiple chemical sensitivity [MCS] | 1.1 | 0.1 | 10 |
| Multiple Sclerosis | 5.5 | 5.1 | 0.08 |
| Multiple system atrophy (MSA) | 1.1 | 0.4 | 1.75 |
| myasthenia gravis | 0.9 | 0.7 | 0.29 |
| neuropathic pain | 0.3 | 2.9 | -8.67 |
| Neuropathy (all types) | 0.8 | 2.2 | -1.75 |
| neuropsychiatric disorders (PANDAS, PANS) | 0.7 | 0.7 | |
| Nonalcoholic Fatty Liver Disease (nafld) Nonalcoholic | 5.4 | 3.4 | 0.59 |
| NonCeliac Gluten Sensitivity | 1.4 | 0.6 | 1.33 |
| Obesity | 9.6 | 7.8 | 0.23 |
| obsessive-compulsive disorder | 5.1 | 4.4 | 0.16 |
| Osteoarthritis | 3.3 | 0.9 | 2.67 |
| Osteoporosis | 2.2 | 1.4 | 0.57 |
| pancreatic cancer | 1 | 0.3 | 2.33 |
| Parkinson's Disease | 7.1 | 7.7 | -0.08 |
| Polycystic ovary syndrome | 6.4 | 2.1 | 2.05 |
| Postural orthostatic tachycardia syndrome | 0.2 | 0.6 | -2 |
| Premenstrual dysphoric disorder | 0.7 | 0.4 | 0.75 |
| primary biliary cholangitis | 1.2 | 1.7 | -0.42 |
| Primary sclerosing cholangitis | 2.3 | 2.3 | 0 |
| Psoriasis | 2.3 | 3.5 | -0.52 |
| rheumatoid arthritis (RA),Spondyloarthritis (SpA) | 6.3 | 4.7 | 0.34 |
| Rosacea | 0.9 | 0.7 | 0.29 |
| Schizophrenia | 5 | 2.5 | 1 |
| scoliosis | 0.4 | 0.4 | |
| Sjögren syndrome | 2.7 | 2.9 | -0.07 |
| Sleep Apnea | 1.6 | 1.5 | 0.07 |
| Slow gastric motility / Gastroparesis | 0.7 | 0.3 | 1.33 |
| Small Intestinal Bacterial Overgrowth (SIBO) | 1.8 | 0.4 | 3.5 |
| Stress / posttraumatic stress disorder | 2.8 | 2.4 | 0.17 |
| Systemic Lupus Erythematosus | 4.6 | 1.9 | 1.42 |
| Tic Disorder | 1.2 | 1.8 | -0.5 |
| Tourette syndrome | 0.9 | 0.3 | 2 |
| Type 1 Diabetes | 4 | 3.3 | 0.21 |
| Type 2 Diabetes | 7.9 | 7 | 0.13 |
| Ulcerative colitis | 5.5 | 7.3 | -0.33 |
| Unhealthy Ageing | 5.7 | 2.5 | 1.28 |
| Vitiligo | 1.9 | 1.3 | 0.46 |
