AI Engines For more Details: Perplexity Kagi Labs You
Intestinal Amebiasis: Diloxanide furoate is the drug of choice for the treatment of asymptomatic intestinal amebiasis, which occurs when individuals harbor the Entamoeba histolytica parasite in their intestines without exhibiting symptoms. Unlike other drugs used to treat amebiasis, such as metronidazole or tinidazole, diloxanide furoate specifically targets the cyst stage of the parasite, helping to eradicate the infection and prevent its transmission to others.
Cysticidal Activity: Diloxanide furoate is a luminal amebicide, meaning it acts primarily within the lumen of the intestine to eliminate the cysts of Entamoeba histolytica. It works by inhibiting the growth and multiplication of the parasite within the intestinal tract, leading to its eventual clearance from the body.
Eradication of Infection: Treatment with diloxanide furoate helps to eradicate the Entamoeba histolytica parasite from the intestines, thereby preventing the development of symptomatic disease, such as amebic dysentery or extraintestinal amebiasis. It also reduces the risk of transmission of the parasite to others through fecal-oral contamination.
Minimal Systemic Absorption: Diloxanide furoate is poorly absorbed from the gastrointestinal tract, which limits its systemic exposure and reduces the risk of systemic side effects. This makes it a safe and well-tolerated treatment option for asymptomatic intestinal amebiasis, particularly in comparison to other medications used to treat amebiasis, which may have more significant side effects.
Side Effects: Common side effects of diloxanide furoate are generally mild and transient and may include gastrointestinal symptoms such as abdominal discomfort, nausea, vomiting, diarrhea, or flatulence. These side effects typically resolve spontaneously with continued treatment or upon completion of therapy and do not usually require discontinuation of the medication.
Contraindications: Diloxanide furoate is contraindicated in individuals with known hypersensitivity or allergy to the medication or any of its components. It should be used with caution in pregnant or breastfeeding women and in individuals with impaired hepatic function.
We extend modifiers to include items that changes the parent and child taxa. I.e. for a species, that would be the genus that is belongs to and the strains in the species.
A higher number indicates impact on more bacteria associated with the condition and confidence on the impact.
We have X bacteria high and Y low reported. We find that the modifier reduces some and increases other of these two groups. We just tally: X|reduces + Y|Increase = Positive X|increases + Y|decrease = Negative.
Benefit Ratio:
Numbers above 0 have increasing positive effect.
Numbers below 0 have increasing negative effect.
