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Antipsychotic Effects: Bromperidol exerts its therapeutic effects by blocking dopamine receptors in the brain, particularly the D2 receptor subtype. By antagonizing dopamine transmission, it helps alleviate symptoms of psychosis, such as hallucinations, delusions, and disorganized thinking, commonly seen in conditions like schizophrenia.
Maintenance Therapy: Bromperidol may be used as a maintenance therapy to prevent relapse in individuals with schizophrenia who have responded well to initial treatment. It helps stabilize mood and reduce the risk of recurrence of psychotic symptoms.
Side Effects: Like other antipsychotic medications, bromperidol can cause a range of side effects. Common side effects include drowsiness, dizziness, dry mouth, blurred vision, constipation, and weight gain. These side effects may vary in severity and can affect individuals differently.
Extrapyramidal Symptoms (EPS): Bromperidol, like many other antipsychotic drugs, can cause extrapyramidal symptoms, which are movement disorders characterized by muscle stiffness, tremors, restlessness, and involuntary muscle movements such as tardive dyskinesia. These symptoms can be distressing and may require dose adjustments or additional medications to manage.
Neurological Effects: In rare cases, bromperidol may increase the risk of neuroleptic malignant syndrome (NMS), a potentially life-threatening condition characterized by fever, muscle rigidity, altered mental status, and autonomic dysfunction. Prompt medical attention is essential if symptoms of NMS occur.
Cardiovascular Effects: Bromperidol may prolong the QT interval on electrocardiograms (ECGs), which can increase the risk of ventricular arrhythmias, including torsades de pointes. It should be used with caution in individuals with preexisting cardiovascular conditions or those taking other medications that can prolong the QT interval.
Metabolic Effects: Long-term use of bromperidol may be associated with metabolic side effects such as weight gain, dyslipidemia, and glucose intolerance. Regular monitoring of metabolic parameters, including weight, blood pressure, blood glucose, and lipid levels, is recommended during treatment.
Other Considerations: Bromperidol should not be used in individuals with a history of hypersensitivity to the drug or its components. It is contraindicated in patients with severe central nervous system depression, coma, or Parkinson's disease. Caution is advised when using bromperidol in elderly patients, as they may be more susceptible to side effects.
We extend modifiers to include items that changes the parent and child taxa. I.e. for a species, that would be the genus that is belongs to and the strains in the species.
A higher number indicates impact on more bacteria associated with the condition and confidence on the impact.
We have X bacteria high and Y low reported. We find that the modifier reduces some and increases other of these two groups. We just tally: X|reduces + Y|Increase = Positive β X|increases + Y|decrease = Negative.
Benefit Ratio:
Numbers above 0 have increasing positive effect.
Numbers below 0 have increasing negative effect.