AI Engines For more Details: Perplexity Kagi Labs You
Tuberculosis (TB): D-Cycloserine is used as a second-line treatment for tuberculosis, especially when first-line drugs such as isoniazid and rifampicin are ineffective or when the TB bacteria are resistant to them. It works by inhibiting the synthesis of mycobacterial cell walls, thereby killing the bacteria or preventing their growth.
Multi-Drug Resistant Tuberculosis (MDR-TB): D-Cycloserine is particularly useful in the treatment of multi-drug resistant tuberculosis (MDR-TB), a form of TB that is resistant to at least isoniazid and rifampicin, the two most potent anti-TB drugs. D-Cycloserine is often used in combination with other second-line drugs to effectively treat MDR-TB infections.
Extensively Drug Resistant Tuberculosis (XDR-TB): D-Cycloserine may also be used in the treatment of extensively drug-resistant tuberculosis (XDR-TB), which is resistant to multiple first-line and second-line anti-TB drugs. In combination with other antibiotics, d-cycloserine can help combat XDR-TB infections.
Adverse Effects: Common side effects of d-cycloserine include dizziness, drowsiness, headache, nausea, vomiting, and diarrhea. It can also cause neurological side effects such as confusion, depression, anxiety, and hallucinations, particularly at higher doses. Long-term use of d-cycloserine may lead to peripheral neuropathy.
Monitoring: Patients taking d-cycloserine should be closely monitored for adverse effects, especially neurological side effects. Regular assessment of kidney function and liver function may also be necessary. Dosage adjustments or discontinuation of the medication may be required if severe adverse effects occur.
Drug Interactions: D-Cycloserine may interact with other medications, including certain antidepressants, antipsychotics, and anticonvulsants, potentially leading to increased side effects or reduced efficacy of either drug. Healthcare providers should be aware of potential drug interactions and adjust medication doses as needed.
Treatment Duration: The duration of treatment with d-cycloserine for tuberculosis varies depending on the severity of the infection, the presence of drug resistance, and other factors. Treatment regimens are typically prolonged, often lasting for several months to years, and may involve combination therapy with multiple antibiotics.
We extend modifiers to include items that changes the parent and child taxa. I.e. for a species, that would be the genus that is belongs to and the strains in the species.
A higher number indicates impact on more bacteria associated with the condition and confidence on the impact.
We have X bacteria high and Y low reported. We find that the modifier reduces some and increases other of these two groups. We just tally: X|reduces + Y|Increase = Positive X|increases + Y|decrease = Negative.
Benefit Ratio:
Numbers above 0 have increasing positive effect.
Numbers below 0 have increasing negative effect.
