AI Engines For more Details: Perplexityβ Kagi Labsβ Youβ
Antiparasitic Activity: Tiabendazole exhibits broad-spectrum antiparasitic activity against various parasites, including nematodes (roundworms), cestodes (tapeworms), and trematodes (flukes). It works by interfering with the metabolism and energy production of parasites, leading to their death or expulsion from the body.
Treatment of Intestinal Worm Infections: Tiabendazole is commonly used to treat intestinal worm infections caused by parasites such as pinworms (Enterobius vermicularis), whipworms (Trichuris trichiura), hookworms (Ancylostoma duodenale and Necator americanus), and roundworms (Ascaris lumbricoides). It helps eliminate adult worms and their larvae from the gastrointestinal tract.
Management of Systemic Fungal Infections: In addition to its antiparasitic properties, tiabendazole has been investigated for its antifungal activity. It has demonstrated efficacy against certain fungal infections, including systemic mycoses caused by fungi such as Candida and Aspergillus species. Tiabendazole may be used as an alternative or adjunctive therapy in the treatment of fungal infections, particularly in cases of resistance to other antifungal agents.
Topical Treatment of Dermatological Conditions: Tiabendazole is available in topical formulations for the treatment of certain dermatological conditions caused by parasitic infections or fungi. It may be used to treat cutaneous larva migrans (creeping eruption), a skin infection caused by the larvae of certain hookworm species. Tiabendazole creams or lotions may also be used to treat fungal skin infections such as ringworm (tinea corporis) and pityriasis versicolor.
Adverse Effects: Common side effects associated with tiabendazole therapy may include gastrointestinal disturbances (e.g., nausea, vomiting, diarrhea), headache, dizziness, and allergic reactions (e.g., rash, itching). In rare cases, tiabendazole may cause more serious adverse effects such as liver toxicity, leukopenia (reduced white blood cell count), and hypersensitivity reactions.
Drug Interactions: Tiabendazole may interact with other medications, particularly those metabolized by the liver or that affect liver function. Patients should inform their healthcare providers about all medications, supplements, and herbal products they are taking before starting tiabendazole therapy to avoid potential interactions.
Pregnancy and Lactation: The safety of tiabendazole use during pregnancy and lactation has not been well established. Pregnant or breastfeeding women should consult their healthcare providers before using tiabendazole, and the benefits of treatment should be weighed against the potential risks to the mother and fetus or infant.
We extend modifiers to include items that changes the parent and child taxa. I.e. for a species, that would be the genus that is belongs to and the strains in the species.
A higher number indicates impact on more bacteria associated with the condition and confidence on the impact.
We have X bacteria high and Y low reported. We find that the modifier reduces some and increases other of these two groups. We just tally: X|reduces + Y|Increase = Positive β X|increases + Y|decrease = Negative.
Benefit Ratio:
Numbers above 0 have increasing positive effect.
Numbers below 0 have increasing negative effect.