AI Engines For more Details: Perplexity Kagi Labs You
Blood Pressure Reduction: Penbutolol sulfate works by blocking the action of certain hormones like adrenaline (epinephrine) on the heart and blood vessels. This results in decreased heart rate and relaxation of blood vessels, leading to lower blood pressure.
Management of Angina: By reducing the workload of the heart and improving blood flow to the heart muscle, penbutolol sulfate can help relieve symptoms of angina, such as chest pain or discomfort.
Heart Rhythm Control: Penbutolol sulfate may also help in controlling abnormal heart rhythms (arrhythmias) by stabilizing the heart's electrical activity.
Side Effects: Common side effects of penbutolol sulfate may include dizziness, fatigue, weakness, nausea, stomach upset, diarrhea, and headache. These side effects are often mild and transient, but if they persist or worsen, it's important to inform your healthcare provider.
Bradycardia (Slow Heart Rate): Since penbutolol sulfate decreases heart rate, it can sometimes lead to bradycardia, especially in individuals with preexisting heart conditions. Symptoms of bradycardia may include fainting, dizziness, fatigue, and shortness of breath. Notify your healthcare provider if you experience these symptoms.
Masking Symptoms of Hypoglycemia: Beta-blockers like penbutolol sulfate can mask some of the signs and symptoms of hypoglycemia (low blood sugar), such as rapid heartbeat and trembling. This may be problematic for individuals with diabetes who rely on these symptoms to recognize low blood sugar levels.
Asthma and COPD: Beta-blockers can potentially worsen respiratory conditions such as asthma or chronic obstructive pulmonary disease (COPD) by narrowing the airways. Penbutolol sulfate should be used with caution in individuals with these conditions and may be contraindicated in some cases.
Fatigue and Exercise Tolerance: Some individuals may experience fatigue or reduced exercise tolerance while taking penbutolol sulfate. This can affect physical activities and performance, so it's essential to discuss any changes in activity level with your healthcare provider.
Interactions with Other Medications: Penbutolol sulfate can interact with other medications, including other blood pressure-lowering drugs, certain antidepressants, and medications for diabetes. It's important to inform your healthcare provider about all medications, supplements, and herbal products you are taking to avoid potential interactions.
Withdrawal: Abruptly stopping penbutolol sulfate can lead to rebound hypertension or worsening of heart conditions. If discontinuation is necessary, it should be done gradually under the guidance of a healthcare professional.
| Rank | Probiotic | Impact |
|---|---|---|
| species | Lacticaseibacillus paracasei | Reduces |
| species | Parabacteroides distasonis | Reduces |
We extend modifiers to include items that changes the parent and child taxa. I.e. for a species, that would be the genus that is belongs to and the strains in the species.
A higher number indicates impact on more bacteria associated with the condition and confidence on the impact.
We have X bacteria high and Y low reported. We find that the modifier reduces some and increases other of these two groups. We just tally: X|reduces + Y|Increase = Positive X|increases + Y|decrease = Negative.
Benefit Ratio:
Numbers above 0 have increasing positive effect.
Numbers below 0 have increasing negative effect.
| Condition | Positive Impact | Negative Impact | Benefit Ratio Impact |
|---|---|---|---|
| ADHD | 1.3 | 1.3 | |
| Age-Related Macular Degeneration and Glaucoma | 0.4 | -0.4 | |
| Allergic Rhinitis (Hay Fever) | 0.7 | 0.3 | 1.33 |
| Allergies | 0.8 | 1 | -0.25 |
| Allergy to milk products | 0.3 | 0.4 | -0.33 |
| Alopecia (Hair Loss) | 0.1 | 0.1 | |
| Alzheimer's disease | 0.7 | 1.8 | -1.57 |
| Amyotrophic lateral sclerosis (ALS) Motor Neuron | 0.6 | 0.3 | 1 |
| Ankylosing spondylitis | 0.8 | 0.6 | 0.33 |
| Anorexia Nervosa | 1 | 1.2 | -0.2 |
| Antiphospholipid syndrome (APS) | 0.3 | 0.3 | |
| Asthma | 1 | 0.3 | 2.33 |
| Atherosclerosis | 0.3 | 0.3 | |
| Atrial fibrillation | 1.6 | 1.1 | 0.45 |
| Autism | 1.1 | 2.7 | -1.45 |
| Autoimmune Disease | 0.3 | 0.3 | |
| Barrett esophagus cancer | 0.3 | -0.3 | |
| Biofilm | 0.3 | 0.3 | |
| Bipolar Disorder | 0.7 | 0.3 | 1.33 |
| Brain Trauma | 0.3 | 0.3 | 0 |
| Breast Cancer | 0.3 | -0.3 | |
| Cancer (General) | 0.2 | -0.2 | |
| Carcinoma | 1 | 0.7 | 0.43 |
| Celiac Disease | 0.3 | 1 | -2.33 |
| Cerebral Palsy | 0.3 | 0.3 | 0 |
| Chronic Fatigue Syndrome | 1.2 | 1.4 | -0.17 |
| Chronic Kidney Disease | 0.4 | 0.9 | -1.25 |
| Chronic Obstructive Pulmonary Disease (COPD) | 0.7 | 0.6 | 0.17 |
| Chronic Urticaria (Hives) | 0.3 | 0.1 | 2 |
| Coagulation / Micro clot triggering bacteria | 0.7 | 0.6 | 0.17 |
| Cognitive Function | 1.3 | 0.7 | 0.86 |
| Colorectal Cancer | 1.6 | 0.6 | 1.67 |
| Constipation | 0.6 | 0.9 | -0.5 |
| Coronary artery disease | 0.9 | 0.6 | 0.5 |
| COVID-19 | 1.2 | 3.2 | -1.67 |
| Crohn's Disease | 1.1 | 2.2 | -1 |
| deep vein thrombosis | 0.3 | 0.6 | -1 |
| Denture Wearers Oral Shifts | 0.7 | 0.7 | |
| Depression | 1.6 | 2.5 | -0.56 |
| Dermatomyositis | 0.3 | 0.3 | |
| Eczema | 0.3 | 0.7 | -1.33 |
| Endometriosis | 0.7 | 0.6 | 0.17 |
| Eosinophilic Esophagitis | 0.3 | -0.3 | |
| Epilepsy | 0.3 | 0.6 | -1 |
| Fibromyalgia | 0.6 | 0.5 | 0.2 |
| Functional constipation / chronic idiopathic constipation | 1.3 | 0.8 | 0.63 |
| gallstone disease (gsd) | 0.7 | 0.7 | |
| Gastroesophageal reflux disease (Gerd) including Barrett's esophagus | 0.6 | -0.6 | |
| Generalized anxiety disorder | 0.3 | 0.3 | 0 |
| Glioblastoma | 0.3 | -0.3 | |
| Gout | 0.6 | 0.3 | 1 |
| Graves' disease | 0.7 | 0.6 | 0.17 |
| Gulf War Syndrome | 0.3 | 0.3 | |
| Halitosis | 0.3 | 0.3 | 0 |
| Hashimoto's thyroiditis | 0.3 | 0.3 | 0 |
| Heart Failure | 1.8 | 1.2 | 0.5 |
| hemorrhagic stroke | 0.4 | 0.4 | |
| Hidradenitis Suppurativa | 0.6 | 0.6 | |
| High Histamine/low DAO | 0.3 | -0.3 | |
| hyperglycemia | 0.4 | 0.4 | 0 |
| hypertension (High Blood Pressure | 1.4 | 1.2 | 0.17 |
| Hypoxia | 0.4 | 0.1 | 3 |
| IgA nephropathy (IgAN) | 1 | 0.7 | 0.43 |
| Inflammatory Bowel Disease | 1.4 | 2.5 | -0.79 |
| Insomnia | 1 | 1.2 | -0.2 |
| Intelligence | 0.1 | -0.1 | |
| Intracranial aneurysms | 0.7 | 0.7 | |
| Irritable Bowel Syndrome | 1 | 1.3 | -0.3 |
| ischemic stroke | 1 | 0.3 | 2.33 |
| Liver Cirrhosis | 1.7 | 0.6 | 1.83 |
| Long COVID | 1.3 | 2.5 | -0.92 |
| Low bone mineral density | 0.3 | -0.3 | |
| Lung Cancer | 0.3 | -0.3 | |
| Mast Cell Issues / mastitis | 0.3 | 0.3 | 0 |
| ME/CFS with IBS | 0.3 | 0.3 | |
| ME/CFS without IBS | 0.3 | 0.1 | 2 |
| membranous nephropathy | 0.3 | 0.3 | |
| Menopause | 0.3 | 0.3 | |
| Metabolic Syndrome | 1 | 1 | 0 |
| Mood Disorders | 1.6 | 2.5 | -0.56 |
| multiple chemical sensitivity [MCS] | 0.7 | 0.7 | |
| Multiple Sclerosis | 1.5 | 2.7 | -0.8 |
| Multiple system atrophy (MSA) | 0.3 | -0.3 | |
| myasthenia gravis | 0.3 | 0.3 | |
| neuropathic pain | 0.7 | -0.7 | |
| Neuropathy (all types) | 0.3 | 0.4 | -0.33 |
| neuropsychiatric disorders (PANDAS, PANS) | 0.3 | 0.3 | |
| Nonalcoholic Fatty Liver Disease (nafld) Nonalcoholic | 1 | 1.2 | -0.2 |
| Obesity | 1.5 | 1.9 | -0.27 |
| obsessive-compulsive disorder | 1.6 | 0.7 | 1.29 |
| Osteoarthritis | 0.3 | 0.6 | -1 |
| Osteoporosis | 0.9 | 0.3 | 2 |
| pancreatic cancer | 0.3 | 0.3 | 0 |
| Parkinson's Disease | 1.8 | 2.5 | -0.39 |
| Polycystic ovary syndrome | 1.8 | 1.2 | 0.5 |
| Premenstrual dysphoric disorder | 0.4 | -0.4 | |
| primary biliary cholangitis | 0.3 | 0.3 | 0 |
| Primary sclerosing cholangitis | 0.7 | 0.8 | -0.14 |
| Psoriasis | 0.6 | 1.2 | -1 |
| rheumatoid arthritis (RA),Spondyloarthritis (SpA) | 2 | 0.6 | 2.33 |
| Rosacea | 0.3 | 0.3 | |
| Schizophrenia | 1.3 | 1 | 0.3 |
| scoliosis | 0.9 | -0.9 | |
| Sjögren syndrome | 0.8 | 0.7 | 0.14 |
| Sleep Apnea | 0.6 | 0.3 | 1 |
| Slow gastric motility / Gastroparesis | 0.3 | 0.3 | |
| Small Intestinal Bacterial Overgrowth (SIBO) | 0.3 | 0.3 | |
| Stress / posttraumatic stress disorder | 0.4 | 0.4 | 0 |
| Systemic Lupus Erythematosus | 0.7 | 0.6 | 0.17 |
| Tic Disorder | 0.6 | 0.1 | 5 |
| Tourette syndrome | 0.3 | 0.3 | |
| Type 1 Diabetes | 0.7 | 1 | -0.43 |
| Type 2 Diabetes | 1.3 | 1 | 0.3 |
| Ulcerative colitis | 1 | 0.8 | 0.25 |
| Unhealthy Ageing | 0.3 | 1 | -2.33 |
| Vitiligo | 1.3 | 0.4 | 2.25 |
