Many Actinomyces species are part of the normal microbial flora in the oral cavity, gastrointestinal tract, and genital tract of humans. In these settings, they contribute to the balance of the microbiota and may have beneficial roles.
Pathogenic Potential:
While Actinomyces species are generally commensal, some can become opportunistic pathogens. Actinomyces species can cause infections, most notably actinomycosis. Actinomycosis is a chronic suppurative and granulomatous infection that can occur in various body sites, including the cervicofacial area, thorax, abdomen, and pelvis.
Actinomycosis:
Actinomycosis is characterized by the formation of abscesses, draining sinuses, and the presence of characteristic sulfur granules in the affected tissues. The condition often arises due to disruption of mucosal barriers, allowing Actinomyces to invade deeper tissues. Cervicofacial actinomycosis is one of the more common forms.
Dental Health:
Actinomyces species are commonly found in dental plaque and can be involved in dental caries and periodontal diseases. Maintaining good oral hygiene is important to prevent the overgrowth of potentially pathogenic bacteria.
Pelvic Inflammatory Disease (PID):
In the genital tract, Actinomyces species have been associated with pelvic inflammatory disease (PID), particularly in women with intrauterine devices (IUDs). This is considered a rare complication.
Endocarditis:
Actinomyces species have been implicated in infective endocarditis, particularly in individuals with pre-existing heart valve abnormalities.
Treatment:
Actinomycosis is typically treated with prolonged courses of antibiotics, often involving penicillin or other beta-lactam antibiotics. Surgical drainage and debridement may be necessary in severe cases.
Different labs use different software to read the sample. See this post for more details.
One lab may say you have none, another may say you have a lot! - This may be solely due to the software they are using to estimate.
We deem lab specific values using values from the KM method for each specific lab to be the most reliable.
Desired Levels Suggestions for Actinomyces
Frequency - how often do samples show this bacteria
UD - An alternative statistical algorithm (which factors in the frequency)
Kaltoft-Moldrup Heuristic Using uploaded data
Lab Low and High are calculated using the formula that most labs use: Mean - 2 Standard Deviation to Mean + 2 Standard Deviation
These are values that are computed from lab specific samples (Patent Pending)
Lab
Frequency
UD-Low
UD-High
KM Low
KM High
Lab Low
Lab High
Mean
Median
Standard Deviation
Box Plot Low
Box Plot High
KM Percentile Low
KM Percentile High
Other Labs
3
0
0
7
7130
0
2644
473.5
100
1107.6
0
836
0 %ile
100 %ile
biomesight
68.02
0
70
10
880
0
1531
172.7
60
692.8
0
180
2.3 %ile
97.4 %ile
thorne
100
36
378
0
294
133.5
98
82
72
294
0 %ile
100 %ile
thryve
78.7
0
119
18
789
0
1261
183.4
78
550
0
227
7.2 %ile
96.6 %ile
ubiome
73.38
0
196
15
1769
0
5355
585.5
146
2433.6
0
490
0 %ile
95.9 %ile
External Reference Ranges for Actinomyces
Actinomyces (NCBI 1654) per million
Source of Ranges
Low Boundary
High Boundary
Low Boundary %age
High Boundary %age
Thorne (20/80%ile)
0
80.71
0
0.0081
Lab Teletest
0
500
0
0.05
Metagenomics
0
10000
0
1
PrecisionBiome
0.00019181544485036284
0.008432741276919842
0
0
Statistic by Lab Source for Actinomyces
These desired values are reported from the lab reports
Lab
Frequency Seen
Average
Standard Deviation
Sample Count
Lab Samples
AmericanGut
20 %
0.015 %
0.018 %
3.0
15
BiomeSight
68.888 %
0.016 %
0.086 %
3235.0
4696
BiomeSightRdp
29.032 %
0.011 %
0.02 %
9.0
31
bugspeak
100 %
0.016 %
%
1.0
1
CerbaLab
66.667 %
0.011 %
0.005 %
2.0
3
CosmosId
87.5 %
0.078 %
0.161 %
28.0
32
custom
10.39 %
0.003 %
0.002 %
8.0
77
es-xenogene
18.75 %
0.016 %
0.013 %
6.0
32
Medivere
87.5 %
0.004 %
0.002 %
7.0
8
Precision
100 %
0.002 %
0.002 %
4.0
4
SequentiaBiotech
28.571 %
0.079 %
0.062 %
10.0
35
Thorne
94.198 %
0.007 %
0.006 %
276.0
293
Thryve
79.78 %
0.018 %
0.07 %
1231.0
1543
Tiny
16.667 %
0.009 %
0.001 %
2.0
12
uBiome
72.195 %
0.059 %
0.243 %
579.0
802
vitract
100 %
0.008 %
0.007 %
2.0
2
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