Treponema phagedenis Details: NCBI 162, gram-negative or unknown [species]

1. Bovine Digital Dermatitis (BDD): Treponema phagedenis is one of the bacteria implicated in the development of bovine digital dermatitis, a common infectious foot disease affecting cattle. BDD causes painful lesions on the hooves of cattle, leading to lameness and decreased productivity in affected animals. It is considered a significant welfare and economic concern in the dairy industry.

2. Interdigital Necrobacillosis: Treponema phagedenis has been associated with interdigital necrobacillosis, also known as footrot or foul in the foot, in sheep and goats. This condition is characterized by inflammation, necrosis, and foul-smelling discharge in the interdigital space, leading to lameness and reduced mobility in affected animals.

3. Swine Necrotic Ear Syndrome (SNES): Treponema phagedenis has been implicated in swine necrotic ear syndrome, a condition characterized by necrotizing inflammation of the ears in pigs. SNES can result in ear necrosis, deformity, and reduced ear mobility, leading to impaired welfare and potential economic losses in pig production.

4. Human Oral Microbiota: While Treponema phagedenis is primarily associated with diseases in animals, it is also part of the human oral microbiota. In the oral cavity, Treponema species can contribute to dental plaque formation and periodontal diseases if the microbial balance is disrupted. However, the specific role of Treponema phagedenis in oral health and disease in humans is not fully understood and requires further research.

Visuals of Interactions with other bacteria of the same rank

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Other Sources for more information:

• Immune Epitope Database
• The NCBI taxonomy database
• UniProt
• Immune Epitope Taxonomy Database (IEDB)
• AI Engines For more Details: Perplexity  Kagi Labs  You 

More Information

Statistics

NCBI

Data Punk

End Products Produced

Lab Reporting

Different labs use different software to read the sample. See this post for more details.
One lab may say you have none, another may say you have a lot! - This may be solely due to the software they are using to estimate.
We deem lab specific values using values from the KM method for each specific lab to be the most reliable.

Desired Levels Suggestions for Treponema phagedenis

• Frequency - how often do samples show this bacteria
• UD - An alternative statistical algorithm (which factors in the frequency)
• Kaltoft-Moldrup Heuristic Using uploaded data
• Lab Low and High are calculated using the formula that most labs use: Mean - 2 Standard Deviation to Mean + 2 Standard Deviation

These are values that are computed from lab specific samples (Patent Pending)

Lab	Frequency	UD-Low	UD-High	KM Low	KM High	Lab Low	Lab High	Mean	Median	Standard Deviation	Box Plot Low	Box Plot High	KM Percentile Low	KM Percentile High
Other Labs	0.09			24	254	0	458	139	139	162.6	24	254	25 %ile	50 %ile
thorne	82.76			1	110	0	66	16.4	8	25.5	0	24	0 %ile	100 %ile

External Reference Ranges for Treponema phagedenis

Treponema phagedenis (NCBI 162) per million

Source of Ranges	Low Boundary	High Boundary	Low Boundary %age	High Boundary %age
PrecisionBiome	1.721544140309561E-05	0.00022967239783611149	0	0

Statistic by Lab Source for Treponema phagedenis

These desired values are reported from the lab reports

Lab	Frequency Seen	Average	Standard Deviation	Sample Count	Lab Samples
CerbaLab	66.667 %	0.014 %	0.016 %	2.0	3
Thorne	80.743 %	0.001 %	0.001 %	239.0	296

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Data Contradictions — Limits of Certainity

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General Substance	Specific Substance	Effect
Amino Acid and similar	2-Amino-5-(carbamoylamino)pentanoic acid {Citrulline}	1 Studies recorded. The consensus is Decreases📓, Click for details.
Amino Acid and similar	Lycopene {Glucosamine (GS)}	1 Studies recorded. The consensus is Decreases📓, Click for details.
Amino Acid and similar	N-[2-(5-methoxy-1H-indol-3-yl)ethyl]acetamide {Melatonin}	2 Studies recorded. The consensus is Decreases📓, Click for details.
Antibiotics, Antivirals etc	doxycycline [CFS]	1 Studies recorded. The consensus is Decreases📓, Click for details.
Antibiotics, Antivirals etc	erythromycin [CFS]	1 Studies recorded. The consensus is Decreases📓, Click for details.
Antibiotics, Antivirals etc	metronidazole [CFS]	1 Studies recorded. The consensus is Decreases📓, Click for details.
Common and OTC Supplements	5-Hydroxytryptophan {5-HTP}	1 Studies recorded. The consensus is Decreases📓, Click for details.
Common and OTC Supplements	Boron {Borax}	1 Studies recorded. The consensus is Decreases📓, Click for details.
Diet Style	dietary fiber	2 Studies recorded. The consensus is Increases📓, Click for details.
Diet Style	Fiber, total dietary	1 Studies recorded. The consensus is Increases📓, Click for details.
Diet Style	High-fibre diet {Whole food diet}	1 Studies recorded. The consensus is Increases📓, Click for details.
Diet Style	Slow digestible carbohydrates. {Low Glycemic}	2 Studies recorded. The consensus is Decreases📓, Click for details.
Diet Style	whole-grain diet	1 Studies recorded. The consensus is Decreases📓, Click for details.
Flavonoids, Polyphenols etc	quebracho	1 Studies recorded. The consensus is Increases📓, Click for details.
Food (excluding seasonings)	Amorphophallus konjac {Konjaku flour}	1 Studies recorded. The consensus is Increases📓, Click for details.
Food (excluding seasonings)	fruit	1 Studies recorded. The consensus is Increases📓, Click for details.
Food (excluding seasonings)	fruit/legume fibre	1 Studies recorded. The consensus is Increases📓, Click for details.
Food (excluding seasonings)	Malus domestica {apple}	1 Studies recorded. The consensus is Increases📓, Click for details.
Food (excluding seasonings)	pectin {pectin}	2 Studies recorded. The consensus is Increases📓, Click for details.
Food (excluding seasonings)	tomato powder	1 Studies recorded. The consensus is Decreases📓, Click for details.
Food (excluding seasonings)	wheat	1 Studies recorded. The consensus is Increases📓, Click for details.
Food Preservatives	Disodium fumarate {Fumaric acid disodium salt}	1 Studies recorded. The consensus is Increases📓, Click for details.
Herb or Spice	Diferuloylmethane {Curcumin}	1 Studies recorded. The consensus is Decreases📓, Click for details.
Herb or Spice	Moringa Oleifera	1 Studies recorded. The consensus is Increases📓, Click for details.
Herb or Spice	Pentadigalloylglucose {Tannic Acid}	1 Studies recorded. The consensus is Increases📓, Click for details.
Miscellaneous, food additives, and other odd items	N-(phosphonomethyl)glycine {glyphosate}	1 Studies recorded. The consensus is Decreases📓, Click for details.
Not Classified	Sodium Fluoride {Toothpaste fluoride}	1 Studies recorded. The consensus is Decreases📓, Click for details.
Prebiotics and similar	Amorphophallus konjac {konjac}	1 Studies recorded. The consensus is Increases📓, Click for details.
Prebiotics and similar	arabinogalactan {arabinogalactan}	1 Studies recorded. The consensus is Increases📓, Click for details.
Prebiotics and similar	Carrageenans {Carrageenan}	1 Studies recorded. The consensus is Increases📓, Click for details.
Prebiotics and similar	partially hydrolysed guar gum	1 Studies recorded. The consensus is Increases📓, Click for details.
Prebiotics and similar	Poly[β-D-xylopyranose(1->4)] {Xylan}	1 Studies recorded. The consensus is Increases📓, Click for details.
Prebiotics and similar	Xanthomonas campestris {Xanthan gum}	1 Studies recorded. The consensus is Increases📓, Click for details.
Prescription - Other	helminth infection (prescription)	1 Studies recorded. The consensus is Increases📓, Click for details.
Probiotics	bacillus	1 Studies recorded. The consensus is Increases📓, Click for details.
Probiotics	Bacillus amyloliquefaciens group {B. Amyloliquefaciens}	1 Studies recorded. The consensus is Increases📓, Click for details.
Probiotics	bacillus,lactobacillus,streptococcus,saccharomyces probiotic	1 Studies recorded. The consensus is Increases📓, Click for details.
Probiotics	Bacteroides uniformis {Bacteroides uniformis}	1 Studies recorded. The consensus is Decreases📓, Click for details.
Probiotics	Escherichia coli Nissle 1917 {Mutaflor}	1 Studies recorded. The consensus is Decreases📓, Click for details.
Probiotics	Lacticaseibacillus casei {L. casei}	1 Studies recorded. The consensus is Decreases📓, Click for details.
Probiotics	Ligilactobacillus salivarius {L. salivarius}	1 Studies recorded. The consensus is Increases📓, Click for details.
Sugar and similar	steviol glycosides {Stevia}	1 Studies recorded. The consensus is Increases📓, Click for details.
Vitamins, Minerals and similar	Mixture of Vitamin B? {B Vitamins}	2 Studies recorded. The consensus is Increases📓, Click for details.
Vitamins, Minerals and similar	nicotinic acid {Vitamin B-3}	1 Studies recorded. The consensus is Increases📓, Click for details.
Vitamins, Minerals and similar	Thiamine {Vitamin B1}	1 Studies recorded. The consensus is Increases📓, Click for details.