Methanobrevibacter smithii Details: NCBI 2173, gram-negative or unknown [species]

| ATCC 35061| DSM 861| Methanobrevibacter smithii| Methanobrevibacter smithii Balch and Wolfe 1981| OCM 144| strain PS

1. Digestive processes: Methanobrevibacter smithii is involved in the digestion of dietary carbohydrates in the human gut. It consumes hydrogen produced by other microorganisms during the fermentation of complex carbohydrates and uses it to produce methane. This process helps regulate the microbial ecosystem in the gut and influences the efficiency of energy extraction from the diet.

2. Association with obesity: Some studies have suggested an association between the abundance of Methanobrevibacter smithii in the gut microbiota and obesity. Methane production by Methanobrevibacter smithii may influence energy metabolism and contribute to increased energy harvest from the diet. However, the exact mechanisms underlying this association and whether Methanobrevibacter smithii directly contributes to obesity or is simply a marker of dysbiosis are still under investigation.

3. Inflammatory bowel disease (IBD): Methanobrevibacter smithii has been detected in the gut microbiota of individuals with inflammatory bowel disease (IBD), including Crohn's disease and ulcerative colitis. However, its role in the pathogenesis of IBD is not fully understood. Some studies have suggested that methane production by Methanobrevibacter smithii may have anti-inflammatory effects in the gut, while others have proposed that it may exacerbate intestinal inflammation by altering microbial interactions.

4. Hydrogen disposal: Methanobrevibacter smithii plays a role in hydrogen disposal in the gut by consuming hydrogen produced during microbial fermentation. In conditions where excess hydrogen accumulates in the gut, such as small intestinal bacterial overgrowth (SIBO), methane production by Methanobrevibacter smithii may help alleviate symptoms associated with hydrogen accumulation, such as bloating and abdominal discomfort.

5. Potential therapeutic target: Given its abundance and potential role in gut health and disease, Methanobrevibacter smithii has been proposed as a potential therapeutic target for modulating the gut microbiota. Strategies aimed at selectively targeting Methanobrevibacter smithii, such as antimicrobial treatments or dietary interventions, are being investigated for their potential to modulate methane production and improve gastrointestinal health.

Visuals of Interactions with other bacteria of the same rank

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Other Sources for more information:

• Immune Epitope Database
• The NCBI taxonomy database
• UniProt
• Immune Epitope Taxonomy Database (IEDB)
• AI Engines For more Details: Perplexity  Kagi Labs  You 

More Information

Statistics

NCBI

Data Punk

End Products Produced

Lab Reporting

Different labs use different software to read the sample. See this post for more details.
One lab may say you have none, another may say you have a lot! - This may be solely due to the software they are using to estimate.
We deem lab specific values using values from the KM method for each specific lab to be the most reliable.

Desired Levels Suggestions for Methanobrevibacter smithii

• Frequency - how often do samples show this bacteria
• UD - An alternative statistical algorithm (which factors in the frequency)
• Kaltoft-Moldrup Heuristic Using uploaded data
• Lab Low and High are calculated using the formula that most labs use: Mean - 2 Standard Deviation to Mean + 2 Standard Deviation

These are values that are computed from lab specific samples (Patent Pending)

Lab	Frequency	UD-Low	UD-High	KM Low	KM High	Lab Low	Lab High	Mean	Median	Standard Deviation	Box Plot Low	Box Plot High	KM Percentile Low	KM Percentile High
Other Labs	1.15			5	477000	0	208030	27126.2	7000	92298.1	0	27911	0 %ile	100 %ile
biomesight	22.42	0	20	10	9990	0	10419	1372.2	300	4615.6	0	1800	0 %ile	97.9 %ile
thryve	19.49	0	15	1	51440	0	16984	3418.6	696	6921.2	0	5204	0 %ile	100 %ile
ubiome	26.36	0	361	21	86128	0	41124	11576.9	5460	15075.3	0	25231	0 %ile	100 %ile

External Reference Ranges for Methanobrevibacter smithii

Methanobrevibacter smithii (NCBI 2173) per million

Source of Ranges	Low Boundary	High Boundary	Low Boundary %age	High Boundary %age
Thorne (20/80%ile)	0	190.4	0	0.019
Medivere	0	300	0	0.03
XenoGene	0	700	0	0.07
PrecisionBiome	3.212152296327986E-05	0.18774661421775818	0	0

Statistic by Lab Source for Methanobrevibacter smithii

These desired values are reported from the lab reports

Lab	Frequency Seen	Average	Standard Deviation	Sample Count	Lab Samples
BiomeSight	22.663 %	0.097 %	0.347 %	1006.0	4439
bugspeak	100 %	0.007 %	%	1.0	1
CerbaLab	66.667 %	0.001 %	0 %	2.0	3
CosmosId	9.375 %	0.468 %	0.407 %	3.0	32
custom	35.616 %	1.482 %	0.555 %	26.0	73
es-xenogene	53.125 %	3.576 %	11.413 %	17.0	32
GanzimmunDiag	100 %	0.012 %	0.003 %	6.0	6
Microba	14.286 %	1.472 %	0.768 %	4.0	28
Microba1	100 %	2.67 %	%	1.0	1
SequentiaBiotech	2.857 %	0.274 %	%	1.0	35
Thorne	25.735 %	0.091 %	0.18 %	70.0	272
Thryve	20 %	0.302 %	0.661 %	307.0	1535
uBiome	26.19 %	1.169 %	1.513 %	209.0	798

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Data Contradictions — Limits of Certainity

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General Substance	Specific Substance	Effect
Antibiotics, Antivirals etc	ampicillin [CFS]	1 Studies recorded. The consensus is Increases👶, Click for details.
Antibiotics, Antivirals etc	bacitracin (antibiotic)	1 Studies recorded. The consensus is Decreases👶, Click for details.
Antibiotics, Antivirals etc	gentamicin	1 Studies recorded. The consensus is Increases👶, Click for details.
Antibiotics, Antivirals etc	metronidazole [CFS]	1 Studies recorded. The consensus is Decreases👶, Click for details.
Antibiotics, Antivirals etc	ofloxacin	1 Studies recorded. The consensus is Increases👶, Click for details.
Antibiotics, Antivirals etc	ornidazole	1 Studies recorded. The consensus is Decreases👶, Click for details.
Antibiotics, Antivirals etc	rifampicin	1 Studies recorded. The consensus is Increases👶, Click for details.
Antibiotics, Antivirals etc	squalamine	1 Studies recorded. The consensus is Decreases👶, Click for details.
Antibiotics, Antivirals etc	streptomycin	1 Studies recorded. The consensus is Increases👶, Click for details.
Antibiotics, Antivirals etc	tetracycline	1 Studies recorded. The consensus is Increases👶, Click for details.
Diet Style	dietary fiber	3 Studies recorded. The consensus is Increases📓, Click for details.
Diet Style	Fiber, total dietary	2 Studies recorded. The consensus is Decreases📓, Click for details.
Diet Style	High-fibre diet {Whole food diet}	2 Studies recorded. The consensus is Decreases📓, Click for details.
Diet Style	High-protein diet {Atkins low-carbohydrate diet}	1 Studies recorded. The consensus is Increases📓, Click for details.
Diet Style	Slow digestible carbohydrates. {Low Glycemic}	2 Studies recorded. The consensus is Decreases📓, Click for details.
Drug or "Non-drug"	amphotericin	1 Studies recorded. The consensus is Increases👶, Click for details.
Flavonoids, Polyphenols etc	3,5,7-trihydroxy flavanone-7-rhamnoglucoside {Hesperidin}	1 Studies recorded. The consensus is Decreases📓, Click for details.
Flavonoids, Polyphenols etc	Humulus lupulus compound {Xanthohumol}	1 Studies recorded. The consensus is Increases📓, Click for details.
Food (excluding seasonings)	Dodecanoic acid {Lauric acid}	2 Studies recorded. The consensus is Decreases👶📓, Click for details.
Food (excluding seasonings)	Elaeis guineensis {Palm oil}	1 Studies recorded. The consensus is Decreases📓, Click for details.
Food (excluding seasonings)	fruit	2 Studies recorded. The consensus is Decreases📓, Click for details.
Food (excluding seasonings)	fruit/legume fibre	2 Studies recorded. The consensus is Decreases📓, Click for details.
Food (excluding seasonings)	Glycerol	1 Studies recorded. The consensus is Increases📓, Click for details.
Food (excluding seasonings)	Humulus lupulus {Hops}	1 Studies recorded. The consensus is Increases📓, Click for details.
Food (excluding seasonings)	Myristica fragrans {Nutmeg}	1 Studies recorded. The consensus is Decreases👶, Click for details.
Food (excluding seasonings)	olive oil {olive oil}	1 Studies recorded. The consensus is Decreases📓, Click for details.
Food (excluding seasonings)	Orange Juice	1 Studies recorded. The consensus is Decreases📓, Click for details.
Food (excluding seasonings)	Oryza sativa {Rice}	1 Studies recorded. The consensus is Increases👶, Click for details.
Food (excluding seasonings)	pectin {pectin}	1 Studies recorded. The consensus is Increases📓, Click for details.
Food (excluding seasonings)	Punica granatum {pomegranate}	1 Studies recorded. The consensus is Decreases📓, Click for details.
Food (excluding seasonings)	sarcodiotheca gaudichaudii {Red Seaweed}	1 Studies recorded. The consensus is Decreases📓, Click for details.
Herb or Spice	3,4-dihydroxyphenyllactic acid {Rosmarinic acid}	1 Studies recorded. The consensus is Decreases📓, Click for details.
Herb or Spice	Ginkgo biloba {Ginkgo}	1 Studies recorded. The consensus is Decreases📓, Click for details.
Miscellaneous, food additives, and other odd items	Animal cohabitation {Owning a Pet}	1 Studies recorded. The consensus is Increases📓, Click for details.
Miscellaneous, food additives, and other odd items	bisphenol a {bpa}	1 Studies recorded. The consensus is Increases📓, Click for details.
Miscellaneous, food additives, and other odd items	cholic,taurocholic ,chenodeoxycholic,glycocholic acids {Bile supplements}	1 Studies recorded. The consensus is Decreases👶, Click for details.
Prebiotics and similar	Plantago {Psyllium}	1 Studies recorded. The consensus is Decreases📓, Click for details.
Prebiotics and similar	xylooligosaccharide	1 Studies recorded. The consensus is Increases📓, Click for details.
Prescription - Other	ethinylestradiol,(prescription)	1 Studies recorded. The consensus is Increases📓, Click for details.
Prescription - Other	lovastatin,(prescription)	1 Studies recorded. The consensus is Decreases👶, Click for details.
Prescription - Other	statins (prescription)	1 Studies recorded. The consensus is Decreases👶, Click for details.
Probiotics	Lacticaseibacillus rhamnosus {l. rhamnosus}	1 Studies recorded. The consensus is Decreases📓, Click for details.
Probiotics	lactobacillus rhamnosus gg	1 Studies recorded. The consensus is Increases📓, Click for details.
Probiotics	lactobacillus rhamnosus gg,bifidobacterium animalis lactis ,lactobacillus paracasei {cvs maximum strength probiotic}	1 Studies recorded. The consensus is Increases📓, Click for details.
Sugar and similar	ß-(1?4)-linked D-glucosamine and N-acetyl-D-glucosamine {Chitosan}	1 Studies recorded. The consensus is Increases👶, Click for details.
Vitamins, Minerals and similar	ascorbic acid {Vitamin C}	1 Studies recorded. The consensus is Increases📓, Click for details.
Vitamins, Minerals and similar	Zinc {Zinc Supplements}	2 Studies recorded. The consensus is Increases👶📓, Click for details.